Eruptive squamous cell carcinomas associated with programmed cell death protein-1 inhibitor therapy

Sir, We would like to present a case of eruptive squamous cell carcinomas (SCC) associated with programmed cell death protein 1 (PD-1) inhibitors and propose topical corticosteroids as a possible first-line therapy. Initially, four representative lesions were sampled and histopathology revealed atyp...

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Published in:Indian journal of dermatology, venereology, and leprology venereology, and leprology, 2019-01, Vol.85 (1), p.97-100
Main Authors: Lee, Jack, Guffey, Darren, Noland, Mary-Margaret, Russell, Mark
Format: Article
Language:English
Subjects:
Apoptosis
Cell death
Consent
Dermatitis
Histopathology
Immunotherapy
Melanoma
Metastasis
Patients
Skin
Skin cancer
Squamous cell carcinoma
Tumors
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Summary:Sir, We would like to present a case of eruptive squamous cell carcinomas (SCC) associated with programmed cell death protein 1 (PD-1) inhibitors and propose topical corticosteroids as a possible first-line therapy. Initially, four representative lesions were sampled and histopathology revealed atypical squamous proliferations with variable-sized islands of keratinocytes with increased nuclear-to-cytoplasm ratios and a scattered dermal lichenoid infiltrate composed largely of lymphocytes, which was consistent with invasive well-differentiated SCC [Figure 2]a,[Figure 2]b,[Figure 2]c. The prednisone taper was completed, and his new lesions were treated with triamcinolone 0.1% ointment to be applied twice daily. {Table 1} In our eruptive SCC case and the nine cases of other eruptive skin neoplasms cited in the literature, lesions occurred in sun-exposed areas of the trunk and extremities, curiously sparing the head and neck in all except the case featuring the mixed eruption.
ISSN:0378-6323
0973-3922
1998-3611
DOI:10.4103/ijdvl.IJDVL_147_18