Excessive alcohol intake enhances the development of synchronous cancerous lesion in colorectal cancer patients

We examined the potential impact of alcohol drinking on the incidence of synchronous colorectal cancer. This study comprised 191 men with colorectal cancer who had undergone surgical resection. Synchronous colorectal cancer was found in 16 patients (8.4%). The relationship between synchronous colore...

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Bibliographic Details
Published in:International journal of colorectal disease 2004-03, Vol.19 (2), p.171-175
Main Authors: MAEKAWA, Shu-Ji, AOYAMA, Nobuo, SHIRASAKA, Daisuke, KURODA, Kohei, TAMURA, Takao, KURODA, Yoshikazu, KASUGA, Masato
Format: Article
Language:English
Subjects:
Adenocarcinoma - etiology
Adenocarcinoma - pathology
Aged
Alcohol Drinking - adverse effects
Alcoholism - complications
Biological and medical sciences
Case-Control Studies
Colorectal cancer
Colorectal Neoplasms - etiology
Colorectal Neoplasms - pathology
Dose-Response Relationship, Drug
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Male
Medical sciences
Multivariate Analysis
Neoplasms, Multiple Primary - etiology
Neoplasms, Multiple Primary - pathology
Odds Ratio
Risk Factors
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Tumors
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Summary:We examined the potential impact of alcohol drinking on the incidence of synchronous colorectal cancer. This study comprised 191 men with colorectal cancer who had undergone surgical resection. Synchronous colorectal cancer was found in 16 patients (8.4%). The relationship between synchronous colorectal cancer and alcohol intake was analyzed by multivariate methods. Cumulative alcohol intake was assessed by the drinking index (weekly average multiplied by years of drinking). There was higher incidence of associated adenoma in the synchronous cancer group. Heavy cumulative intake (drinking index 9800 or higher) was associated with significantly higher risk synchronous colorectal cancer than in nondrinkers (odds ratio 6.8). The association of alcohol intake with the risk of synchronous colorectal cancer was not affected by the type of alcohol beverages. This study demonstrated that excessive alcohol intake might be an independent risk factor for synchronous colorectal cancer. The screening program based on this information may prevent the synchronous lesions being missed.
ISSN:0179-1958
1432-1262
DOI:10.1007/s00384-003-0516-x