Effect of antithyroid drugs on the occurrence of antibodies against type 2 deiodinase (DIO2), which are involved in hyperthyroid Graves’ disease influencing the therapeutic efficacy

Graves’ disease is an organ-specific autoimmune disease with hyperthyroidism, diffuse goiter and autoantibodies against TSH receptor, thyroid peroxidase (TPO) and/or thyroglobulin (Tg). Graves’ hyperthyroidism is characterized by T 3 dominance due to the conversion of T 4 into T 3 through type 1 and...

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Bibliographic Details
Published in:Clinical and experimental medicine 2019-05, Vol.19 (2), p.245-254
Main Authors: Molnár, Ildikó, Szentmiklósi, József A., Gesztelyi, Rudolf, Somogyiné-Vári, Éva
Format: Article
Language:English
Subjects:
Adult
Antithyroid Agents - administration & dosage
Autoantibodies
Autoantibodies - blood
Drugs
Enzymes
Female
Goiter
Graves Disease - drug therapy
Graves Disease - pathology
Graves' disease
Hematology
Humans
Hyperthyroidism
Immunoglobulins
Internal Medicine
Iodide peroxidase
Iodide Peroxidase - immunology
Iodothyronine Deiodinase Type II
Male
Medicine
Medicine & Public Health
Methimazole - administration & dosage
Middle Aged
Oncology
Original Article
Peptides
Peroxidase
Propylthiouracil
Propylthiouracil - administration & dosage
Thyroglobulin
Thyroid
Thyroid gland
Thyroid-stimulating hormone
Thyroxine
Treatment Outcome
Triiodothyronine
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Description
Summary:Graves’ disease is an organ-specific autoimmune disease with hyperthyroidism, diffuse goiter and autoantibodies against TSH receptor, thyroid peroxidase (TPO) and/or thyroglobulin (Tg). Graves’ hyperthyroidism is characterized by T 3 dominance due to the conversion of T 4 into T 3 through type 1 and 2 deiodinase enzymes (DIO1, DIO2). Methimazole (MMI) and propylthiouracil (PTU) therapies inhibit thyroid hormone synthesis blocking the activity of deiodinase and TPO enzymes. The study investigated the occurrence of autoantibodies against DIO2 peptides (cys- and hom-peptides) with the effect of antithyroid drugs on their frequencies in 78 patients with Graves’ disease and 30 controls. In hyperthyroidism, the presence of DIO2 peptide antibodies was as follows: 20 and 11 cases out of 51 for cys- and hom-peptide antibodies, respectively, of whom 8 cases possessed antibodies against both peptides. Antithyroid drugs differently influenced their frequencies, which were greater in PTU than in MMI (3/6 vs 13/45 cases, P  
ISSN:1591-8890
1591-9528
DOI:10.1007/s10238-018-00542-7