Mitochondrial Transport of Cations: Channels, Exchangers, and Permeability Transition

Department of Biomedical Sciences, University of Padova, and Consiglio Nazionale delle Ricerche Center for the Study of Biomembranes, Padova, Italy Bernardi, Paolo Mitochondrial Transport of Cations: Channels, Exchangers, and Permeability Transition. J. Neurophysiol. 79: 1127-1155, 1999. This review...

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Bibliographic Details
Published in:Physiological reviews 1999-10, Vol.79 (4), p.1127-1155
Main Author: Bernardi, Paolo
Format: Article
Language:English
Subjects:
Anatomy & physiology
Animals
Calcium - metabolism
Calcium channels
Carrier Proteins - metabolism
Cations
Cations - metabolism
Cellular biology
Humans
Intracellular Membranes - metabolism
Ion channels
Ion Channels - metabolism
Magnesium - metabolism
Mitochondria
Mitochondria - metabolism
Permeability
Physiological aspects
Potassium - metabolism
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Summary:Department of Biomedical Sciences, University of Padova, and Consiglio Nazionale delle Ricerche Center for the Study of Biomembranes, Padova, Italy Bernardi, Paolo Mitochondrial Transport of Cations: Channels, Exchangers, and Permeability Transition. J. Neurophysiol. 79: 1127-1155, 1999. This review provides a selective history of how studies of mitochondrial cation transport (K + , Na + , Ca 2+ ) developed in relation to the major themes of research in bioenergetics. It then covers in some detail specific transport pathways for these cations, and it introduces and discusses open problems about their nature and physiological function, particularly in relation to volume regulation and Ca 2+ homeostasis. The review should provide the basic elements needed to understand both earlier mitochondrial literature and current problems associated with mitochondrial transport of cations and hopefully will foster new interest in the molecular definition of mitochondrial cation channels and exchangers as well as their roles in cell physiology.
ISSN:0031-9333
1522-1210
DOI:10.1152/physrev.1999.79.4.1127