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Mitochondrial Transport of Cations: Channels, Exchangers, and Permeability Transition
Department of Biomedical Sciences, University of Padova, and Consiglio Nazionale delle Ricerche Center for the Study of Biomembranes, Padova, Italy Bernardi, Paolo Mitochondrial Transport of Cations: Channels, Exchangers, and Permeability Transition. J. Neurophysiol. 79: 1127-1155, 1999. This review...
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| Published in: | Physiological reviews 1999-10, Vol.79 (4), p.1127-1155 |
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| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c561t-2991c59dd63088d616833a3fccf17c244e16dd67ee4e3b04d79c05ee69aacb803 |
| container_end_page | 1155 |
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| container_title | Physiological reviews |
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| creator | Bernardi, Paolo |
| description | Department of Biomedical Sciences, University of Padova, and
Consiglio Nazionale delle Ricerche Center for the Study of
Biomembranes, Padova, Italy
Bernardi, Paolo
Mitochondrial Transport of Cations: Channels, Exchangers, and
Permeability Transition. J. Neurophysiol. 79: 1127-1155, 1999. This review provides a selective history of how
studies of mitochondrial cation transport (K + ,
Na + , Ca 2+ ) developed in relation to the major
themes of research in bioenergetics. It then covers in some detail
specific transport pathways for these cations, and it introduces and
discusses open problems about their nature and physiological function,
particularly in relation to volume regulation and Ca 2+
homeostasis. The review should provide the basic elements needed to
understand both earlier mitochondrial literature and current problems
associated with mitochondrial transport of cations and hopefully will
foster new interest in the molecular definition of mitochondrial cation
channels and exchangers as well as their roles in cell physiology. |
| doi_str_mv | 10.1152/physrev.1999.79.4.1127 |
| format | article |
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Consiglio Nazionale delle Ricerche Center for the Study of
Biomembranes, Padova, Italy
Bernardi, Paolo
Mitochondrial Transport of Cations: Channels, Exchangers, and
Permeability Transition. J. Neurophysiol. 79: 1127-1155, 1999. This review provides a selective history of how
studies of mitochondrial cation transport (K + ,
Na + , Ca 2+ ) developed in relation to the major
themes of research in bioenergetics. It then covers in some detail
specific transport pathways for these cations, and it introduces and
discusses open problems about their nature and physiological function,
particularly in relation to volume regulation and Ca 2+
homeostasis. The review should provide the basic elements needed to
understand both earlier mitochondrial literature and current problems
associated with mitochondrial transport of cations and hopefully will
foster new interest in the molecular definition of mitochondrial cation
channels and exchangers as well as their roles in cell physiology.</description><identifier>ISSN: 0031-9333</identifier><identifier>EISSN: 1522-1210</identifier><identifier>DOI: 10.1152/physrev.1999.79.4.1127</identifier><identifier>PMID: 10508231</identifier><identifier>CODEN: PHREA7</identifier><language>eng</language><publisher>United States: Am Physiological Soc</publisher><subject>Anatomy & physiology ; Animals ; Calcium - metabolism ; Calcium channels ; Carrier Proteins - metabolism ; Cations ; Cations - metabolism ; Cellular biology ; Humans ; Intracellular Membranes - metabolism ; Ion channels ; Ion Channels - metabolism ; Magnesium - metabolism ; Mitochondria ; Mitochondria - metabolism ; Permeability ; Physiological aspects ; Potassium - metabolism</subject><ispartof>Physiological reviews, 1999-10, Vol.79 (4), p.1127-1155</ispartof><rights>COPYRIGHT 1999 American Physiological Society</rights><rights>Copyright American Physiological Society Oct 1999</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c561t-2991c59dd63088d616833a3fccf17c244e16dd67ee4e3b04d79c05ee69aacb803</citedby><cites>FETCH-LOGICAL-c561t-2991c59dd63088d616833a3fccf17c244e16dd67ee4e3b04d79c05ee69aacb803</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10508231$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bernardi, Paolo</creatorcontrib><title>Mitochondrial Transport of Cations: Channels, Exchangers, and Permeability Transition</title><title>Physiological reviews</title><addtitle>Physiol Rev</addtitle><description>Department of Biomedical Sciences, University of Padova, and
Consiglio Nazionale delle Ricerche Center for the Study of
Biomembranes, Padova, Italy
Bernardi, Paolo
Mitochondrial Transport of Cations: Channels, Exchangers, and
Permeability Transition. J. Neurophysiol. 79: 1127-1155, 1999. This review provides a selective history of how
studies of mitochondrial cation transport (K + ,
Na + , Ca 2+ ) developed in relation to the major
themes of research in bioenergetics. It then covers in some detail
specific transport pathways for these cations, and it introduces and
discusses open problems about their nature and physiological function,
particularly in relation to volume regulation and Ca 2+
homeostasis. The review should provide the basic elements needed to
understand both earlier mitochondrial literature and current problems
associated with mitochondrial transport of cations and hopefully will
foster new interest in the molecular definition of mitochondrial cation
channels and exchangers as well as their roles in cell physiology.</description><subject>Anatomy & physiology</subject><subject>Animals</subject><subject>Calcium - metabolism</subject><subject>Calcium channels</subject><subject>Carrier Proteins - metabolism</subject><subject>Cations</subject><subject>Cations - metabolism</subject><subject>Cellular biology</subject><subject>Humans</subject><subject>Intracellular Membranes - metabolism</subject><subject>Ion channels</subject><subject>Ion Channels - metabolism</subject><subject>Magnesium - metabolism</subject><subject>Mitochondria</subject><subject>Mitochondria - metabolism</subject><subject>Permeability</subject><subject>Physiological aspects</subject><subject>Potassium - metabolism</subject><issn>0031-9333</issn><issn>1522-1210</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><recordid>eNptkUFv1DAUhC0EokvhL1QRB07NYseJHXOrVi0gFcFhe7a8zkviyrEXOyndf49DthShlQ-23vtmNNYgdEHwmpCq-LjvDzHAw5oIIdZcrMs0LvgLtErLIicFwS_RCmNKckEpPUNvYrzHGFcVq16jM4IrXBeUrNDdNzN63XvXBKNstg3Kxb0PY-bbbKNG4138lG165RzYeJldP-r07iCkt3JN9gPCAGpnrBkPi9jMmrfoVatshHfH-xzd3VxvN1_y2--fv26ubnNdMTLmhRBEV6JpGMV13TDCakoVbbVuCddFWQJhackBSqA7XDZcaFwBMKGU3tWYnqMPi-8--J8TxFEOJmqwVjnwU5Qc87oQvErg-__Aez8Fl7LJgrCyZmUxQ5cL1CkL0rjWj0HpDhwEZb2D1qTxVcUZFYLXCc9P4Ok0MBh9imcLr4OPqbxW7oMZVDhIguVcqjyWKudSJReylHOpSXhxDD_tBmj-kS0tJqBegN50_S8T4I-T8dZ3B3kzWbuFx_HJ_a-v3Dft859PSZ_yPEf5DcyaxGg</recordid><startdate>19991001</startdate><enddate>19991001</enddate><creator>Bernardi, Paolo</creator><general>Am Physiological Soc</general><general>American Physiological Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>7TS</scope><scope>7X8</scope></search><sort><creationdate>19991001</creationdate><title>Mitochondrial Transport of Cations: Channels, Exchangers, and Permeability Transition</title><author>Bernardi, Paolo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c561t-2991c59dd63088d616833a3fccf17c244e16dd67ee4e3b04d79c05ee69aacb803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Anatomy & physiology</topic><topic>Animals</topic><topic>Calcium - metabolism</topic><topic>Calcium channels</topic><topic>Carrier Proteins - metabolism</topic><topic>Cations</topic><topic>Cations - metabolism</topic><topic>Cellular biology</topic><topic>Humans</topic><topic>Intracellular Membranes - metabolism</topic><topic>Ion channels</topic><topic>Ion Channels - metabolism</topic><topic>Magnesium - metabolism</topic><topic>Mitochondria</topic><topic>Mitochondria - metabolism</topic><topic>Permeability</topic><topic>Physiological aspects</topic><topic>Potassium - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bernardi, Paolo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>MEDLINE - Academic</collection><jtitle>Physiological reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bernardi, Paolo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mitochondrial Transport of Cations: Channels, Exchangers, and Permeability Transition</atitle><jtitle>Physiological reviews</jtitle><addtitle>Physiol Rev</addtitle><date>1999-10-01</date><risdate>1999</risdate><volume>79</volume><issue>4</issue><spage>1127</spage><epage>1155</epage><pages>1127-1155</pages><issn>0031-9333</issn><eissn>1522-1210</eissn><coden>PHREA7</coden><abstract>Department of Biomedical Sciences, University of Padova, and
Consiglio Nazionale delle Ricerche Center for the Study of
Biomembranes, Padova, Italy
Bernardi, Paolo
Mitochondrial Transport of Cations: Channels, Exchangers, and
Permeability Transition. J. Neurophysiol. 79: 1127-1155, 1999. This review provides a selective history of how
studies of mitochondrial cation transport (K + ,
Na + , Ca 2+ ) developed in relation to the major
themes of research in bioenergetics. It then covers in some detail
specific transport pathways for these cations, and it introduces and
discusses open problems about their nature and physiological function,
particularly in relation to volume regulation and Ca 2+
homeostasis. The review should provide the basic elements needed to
understand both earlier mitochondrial literature and current problems
associated with mitochondrial transport of cations and hopefully will
foster new interest in the molecular definition of mitochondrial cation
channels and exchangers as well as their roles in cell physiology.</abstract><cop>United States</cop><pub>Am Physiological Soc</pub><pmid>10508231</pmid><doi>10.1152/physrev.1999.79.4.1127</doi><tpages>29</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Physiological reviews, 1999-10, Vol.79 (4), p.1127-1155 |
| issn | 0031-9333 1522-1210 |
| language | eng |
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| source | American Physiological Society:Jisc Collections:American Physiological Society Journals ‘Read Publish & Join’ Agreement:2023-2024 (Reading list); American Physiological Society Free |
| subjects | Anatomy & physiology Animals Calcium - metabolism Calcium channels Carrier Proteins - metabolism Cations Cations - metabolism Cellular biology Humans Intracellular Membranes - metabolism Ion channels Ion Channels - metabolism Magnesium - metabolism Mitochondria Mitochondria - metabolism Permeability Physiological aspects Potassium - metabolism |
| title | Mitochondrial Transport of Cations: Channels, Exchangers, and Permeability Transition |
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