Rebampide enema therapy as a treatment for patients with chronic radiation proctitis: initial treatment or when other methods of conservative management have failed

• Published in: International journal of colorectal disease 2008-06, Vol.23 (6), p.629-633
• Main Authors: Kim, Tae Oh, Song, Geun Am, Lee, Sun Mi, Kim, Gwang Ha, Heo, Jeong, Kang, Dae Hwan, Cho, Mong
• Format: Article
• Language: English
• Subjects: Aged; Alanine - administration & dosage; Alanine - analogs & derivatives; Antioxidants - administration & dosage; Biological and medical sciences; Digestive system; Enema; Female; Gastroenterology; Gastroenterology. Liver. Pancreas. Abdomen; Genital Neoplasms, Female - radiotherapy; Hepatology; Humans; Internal Medicine; Medical sciences; Medicine; Medicine & Public Health; Middle Aged; Original Article; Other diseases. Semiology; Pharmacology. Drug treatments; Proctitis - drug therapy; Proctitis - pathology; Proctology; Quinolones - administration & dosage; Radiation Injuries - drug therapy; Radiation Injuries - pathology; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Surgery
• ISSN: 0179-1958; 1432-1262
• DOI: 10.1007/s00384-008-0453-9

Introduction Radiation proctitis is a common complication following radiation therapy for pelvic malignancies. There have been no formal trials of treatment for radiation proctitis and a variety of methods are currently used. We assessed the efficacy of rebamipide enema to control symptoms and proctoscopic findings from radiation proctitis. Materials and methods Fifteen patients with radiation proctitis were enrolled. Enemas containing 150 mg rebamipide per dosing were administered after morning bowel movement, and always prior to bedtime, twice daily for 4 weeks. The efficacy of treatment was assessed from clinical symptoms (Subjective Objective Management Analysis Scale for Rectal Toxicity) and endoscopic findings. Results The mean bleeding score improved from 2.67 to 0.53 ( P