New triterpenoid saponins from the leaves of Ilex chinensis

Eight new triterpenoid saponins, including four ursane-type saponins, ilexchinenosides J-M (1–4), and four oleanane-type saponins, ilexchinenosides N-Q (5–8), along with three known triterpenoid saponins (9–11) were isolated from the leaves of Ilex chinensis Sims. Their structures were established b...

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Bibliographic Details
Published in:Fitoterapia 2018-11, Vol.131, p.134-140
Main Authors: Li, Ruo-Fei, Xia, Wen-Qi, Liu, Jia-Bao, Cui, Bao-Song, Hou, Qi, Sun, Hua, Li, Shuai
Format: Article
Language:English
Subjects:
Aminophenol
Aquifoliaceae
Chemical compounds
Chinese medicine
Flowers & plants
hepatoprotective activity
Ilex chinensis
Leaves
Lipopolysaccharides
Macrophages
NMR
NO production inhibitory activity
Nuclear magnetic resonance
p-Aminophenol
Saponins
triterpenoid saponins
Two dimensional analysis
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Summary:Eight new triterpenoid saponins, including four ursane-type saponins, ilexchinenosides J-M (1–4), and four oleanane-type saponins, ilexchinenosides N-Q (5–8), along with three known triterpenoid saponins (9–11) were isolated from the leaves of Ilex chinensis Sims. Their structures were established by 1D, 2D NMR and MS spectroscopic analyses and through comparisons with known compounds. Moreover, compounds 1, 3, 5, 7–9 and 11 exhibited significant levels of hepatoprotective activity against N-acetyl-p-aminophenol (APAP)-induced HepG2 cell damage in in vitro assays while compound 10 had moderately inhibitory effects on the NO production of lipopolysaccharide (LPS)-induced murine macrophages. [Display omitted] •Eight new triterpenoid saponins were isolated from the leaves of Ilex chinensis.•Seven compounds exhibited significant hepatoprotective activity.•One compound exhibited moderate inhibitory activity on NO production.
ISSN:0367-326X
1873-6971
DOI:10.1016/j.fitote.2018.10.007