Biochemical relations between copper, selenium, zinc, and magnesium with the glycemic state of diabetic pregnant women

• Published in: Benha Medical Journal 2018-09, Vol.35 (3), p.344
• Main Authors: Mohammed, RaafatR, Mehrez, MostafaM, Abdel-Maksoud, Hussein
• Format: Article
• Language: English
• Subjects: Chronic illnesses; Copper; Diabetes; Enzymes; Glucose; Homeostasis; Hyperglycemia; Insulin; Metabolism; Pregnancy; Selenium; Statistical analysis; Studies; Urine; Womens health
• ISSN: 1110-208X; 2357-0016
• DOI: 10.4103/bmfj.bmfj_213_17

Background Micronutrients, have specific roles in the metabolism, normal growth, and the pathogenesis and progress of diseases with a specific alteration in diabetic patients. Aim The present study aims to follow up the levels of urinary and serum copper, selenium, zinc, and magnesium (Cu, Se, Zn, and Mg) of pregnant diabetic primigravida and multigravida (second and third pregnancy) women compared with their levels in healthy nondiabetic pregnant ones and their possible association with the glycemic status. Patients and methods Three groups of pregnant diabetic, primigravida women, second pregnancy and third pregnancy with their corresponding nondiabetic pregnant controls were followed up in this study. Results The results of this study showed that the urinary levels of Cu, Se, Zn, and Mg were significantly higher in diabetic pregnant women when matched with healthy controls in all durations of sample collection at the first day of the third, sixth, and ninth months of pregnancy. The results are highly significant at multigravida (second and third pregnancy) than the primigravida ones. However, serum (Cu, Se, Zn, and Mg) levels were decreased all over the pregnancy periods. Conclusion The results confirmed that alterations of urinary levels of Cu, Se, and Zn are associated with diabetes mellitus.