Synthesis and crystal structures of phenylalanine ester-introduced palladium(II) and platinum(II) complexes and their cytotoxicities

Phenylalanine ester-introduced palladium(II) and platinum(II) complexes were synthesized. Taking advantage of the formation of Schiff bases by amino acids as an intermediate, the pyridylimine moiety coordinated to a metal center. Single crystals of each complex were obtained successfully, and their...

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Bibliographic Details
Published in:Research on chemical intermediates 2019-01, Vol.45 (1), p.3-12
Main Authors: Nomoto, Akihiro, Sakamoto, Nozomi, Sakai, Yuta, Fukumoto, Keisuke, Ogura, Shun-Ichiro, Shouhei, Katao, Kakiuchi, Kiyomi, Kikuchi, Jun-ichi, Yano, Shigenobu, Ogawa, Akiya
Format: Article
Language:English
Subjects:
Amino acids
Catalysis
Chemistry
Chemistry and Materials Science
Crystal structure
Crystals
Imines
Inorganic Chemistry
Palladium
Phenylalanine
Physical Chemistry
Platinum
Single crystals
Toxicity
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Summary:Phenylalanine ester-introduced palladium(II) and platinum(II) complexes were synthesized. Taking advantage of the formation of Schiff bases by amino acids as an intermediate, the pyridylimine moiety coordinated to a metal center. Single crystals of each complex were obtained successfully, and their molecular structures were clarified in detail. The Pd(II) complex showed remarkable cytotoxicity compared to the Pt(II) complex.
ISSN:0922-6168
1568-5675
DOI:10.1007/s11164-018-3623-6