Recovery of milk somatic cell count and performance after an intramammary LPS challenge is dependent on the metabolic status of dairy cows

We investigated if the metabolic status prior to an intramammary LPS challenge (LPS-CH) impacts the mammary immune response and recovery. For 15 Holstein cows, weekly blood sampling and daily recording of DMI, milk yield, milk composition, and BW (to calculate energy balance) started 3 wk a.p.. In w...

Full description

Saved in:
Bibliographic Details
Published in:Journal of animal science 2018-12, Vol.96, p.263-263
Main Authors: Gross, J, Grossen-Rösti, L, Wall, S, Wellnitz, O, Bruckmaier, R
Format: Article
Language:English
Subjects:
Blood
Body temperature
Cattle
Dairy cattle
Dairy farms
Diet
Energy balance
Glucose
Immune response
Immune system
Immunoglobulin G
L-Lactate dehydrogenase
Lactate dehydrogenase
Lactic acid
Lipopolysaccharides
Milk
Recording
Recovery
Sampling
Serum albumin
Udder
Yield
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We investigated if the metabolic status prior to an intramammary LPS challenge (LPS-CH) impacts the mammary immune response and recovery. For 15 Holstein cows, weekly blood sampling and daily recording of DMI, milk yield, milk composition, and BW (to calculate energy balance) started 3 wk a.p.. In wk 4 p.p., cows underwent a LPS-CH (50 pg LPS into 1 quarter) with frequent blood and milk sampling. Plasma was analyzed for glucose, NEFA and BHB. In milk, serum albumin (SA), IgG concentration, somatic cell count (SCC) and lactate dehydrogenase (LDH) activity were determined. DMI and milk yield were recorded for a further 6 d. Milk from the LPS treated quarter was sampled for 8 d after the challenge. Based on glucose concentrations in wk 1-4 p.p. prior to LPS-CH, cows were retrospectively grouped into a high (HG, n=7) and low glucose group (LG, n=8). Data were evaluated using mixed models with time, group, timexgroup interaction as fixed effects and cow as repeated subject. Glucose was lower and BHB higher in LG compared to HG before LPS-CH (P0.05), body temperature increased less in HG, BHB and NEFA were higher in LG compared to HG (P
ISSN:0021-8812
1525-3163