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Optical sensors for detection of nano-molar Zn^sup 2+^ in aqueous medium: Direct evidence of probe-Zn^sup 2+^ binding by single crystal X-ray structures
Two simple probes, derived by condensation of ethylenediamine with 3-ethoxysalicylaldehyde (L) and salicylaldehyde (L1) have been exploited for selective recognition of Zn2+. The interaction between probes and Zn2+ has been established by spectroscopic techniques and confirmed by single crystal X-ra...
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Published in: | Journal of photochemistry and photobiology. A, Chemistry. Chemistry., 2019-01, Vol.368, p.52 |
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Main Authors: | , , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Online Access: | Get full text |
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Summary: | Two simple probes, derived by condensation of ethylenediamine with 3-ethoxysalicylaldehyde (L) and salicylaldehyde (L1) have been exploited for selective recognition of Zn2+. The interaction between probes and Zn2+ has been established by spectroscopic techniques and confirmed by single crystal X-ray structures of the resulting Zn2+ complexes. It is proposed that Zn2+ inhibits the PET process, originally responsible for non-emissive nature of free ligand and turns the fluorescence ON through CHEF process. The L and L1 probes respectively detect as low as 1.8 nM and 1.16 nM Zn2+, while corresponding binding constants are 2.9 × 106 M−1 and 4.57 × 105 M−1. L1 is very effective for intra-celullar imaging of Zn2+ in HeLa and MDA-MB-468 cells. The density functional theoretical studies unveil the energy parameters involved in the probe-Zn2+ interaction process. |
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ISSN: | 1010-6030 1873-2666 |
DOI: | 10.1016/j.jphotochem.2018.09.009 |