Detection of ethyl glucuronide in dried human blood using LC-MS/MS

Ethyl glucuronide, as a direct metabolite of ethanol degradation, has proven useful as a long-term marker in many forensic applications. The inability to determine ethyl glucuronide in dried blood left a missing link in many investigations. Here, we describe a new method based on mass spectrometry i...

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Bibliographic Details
Published in:International journal of legal medicine 2008-05, Vol.122 (3), p.245-249
Main Authors: Kaufmann, Eckhard, Alt, Andreas
Format: Article
Language:English
Subjects:
Alcohol Drinking
Alcoholic beverages
Alcoholism
Biomarkers - analysis
Blood Chemical Analysis
Chromatography
Chromatography, Liquid - methods
Crime scenes
Ethanol
Female
Forensic Medicine
Forensic Toxicology
Glucuronates - analysis
Humans
Male
Mass spectrometry
Medical Law
Medicine
Medicine & Public Health
Scientific imaging
Tandem Mass Spectrometry - methods
Technical Note
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Description
Summary:Ethyl glucuronide, as a direct metabolite of ethanol degradation, has proven useful as a long-term marker in many forensic applications. The inability to determine ethyl glucuronide in dried blood left a missing link in many investigations. Here, we describe a new method based on mass spectrometry in a Pauli-type ion trap in order to determine this substance in dried blood samples.
ISSN:0937-9827
1437-1596
DOI:10.1007/s00414-007-0219-x