Cyto(geno)toxicity of Commercial Fungicides Based on the Active Compounds Tebuconazole, Difenoconazole, Procymidone, and Iprodione in Lactuca sativa L. Meristematic Cells

The present work aimed to evaluate the effects of commercial fungicides containing the active compounds from the triazole group—tebuconazole (TBZ) and difenoconazole (DFZ)—and dicarboximide group—procymidone (PRD) and iprodione (IPD) on the mitotic cycle of the plant model Lactuca sativa L. These ac...

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Bibliographic Details
Published in:Water, air, and soil pollution air, and soil pollution, 2019, Vol.230 (1), p.1-9, Article 25
Main Authors: Aragão, Francielen Barroso, Bernardes, Paula Mauri, Ferreira, Adésio, Ferreira, Marcia Flores da Silva, Andrade-Vieira, Larissa Fonseca
Format: Article
Language:English
Subjects:
Atmospheric Protection/Air Quality Control/Air Pollution
Bio-assays
Bioassays
Bridges
Cell cycle
Cells
Chromosomes
Climate Change/Climate Change Impacts
Cytotoxicity
Dicarboximide
Difenoconazole
Earth and Environmental Science
Environment
Environmental monitoring
Fungicides
Hydrogeology
Iprodione
Lactuca sativa
Metaphase
Pesticides
Procymidone
Soil Science & Conservation
Tebuconazole
Toxicity
Water Quality/Water Pollution
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Summary:The present work aimed to evaluate the effects of commercial fungicides containing the active compounds from the triazole group—tebuconazole (TBZ) and difenoconazole (DFZ)—and dicarboximide group—procymidone (PRD) and iprodione (IPD) on the mitotic cycle of the plant model Lactuca sativa L. These active compounds have been present in foods sampled at different Brazilian’s states and amounted higher than recommended by law. The bioassay with L. sativa was applied to access the toxicity and better understand the mechanisms of action of these compounds in living beings. The active principles IPD and DFZ presented mitodepressive effect, statistically reducing the MI at all applied concentrations in comparison to the negative control. TBZ was the most cytotoxic active compound tested inhibited in 77% mitotic active in the lowest concentration applied. PRD alter the frequency of mitotic cells only in the concentration above that recommended by the manufacture. C-metaphase and adherent chromosomes were the most frequent cell cycle alteration observed on the treated cells, followed by bridges and lost chromosomes. Therefore, the mechanism of action was mainly aneugenic (70%). For TBZ, the frequency of condensed nucleus was very expressive (313 higher than the negative control).
ISSN:0049-6979
1573-2932
DOI:10.1007/s11270-019-4080-6