Association between α‐adducin rs4961 polymorphism and hypertension: A meta‐analysis based on 40432 subjects

Background: Recently, the role of α‐adducin rs4961 polymorphism in hypertension (HTN) was intensively analyzed, but the results of these studies were inconsistent. Therefore, we performed this study to better assess the relationship between α‐adducin rs4961 polymorphism and the likelihood of HTN.Met...

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Published in:Journal of cellular biochemistry 2019-03, Vol.120 (3), p.4613-4619
Main Authors: Jin, Hongyan, Huang, Yupeng, Yang, Guokang
Format: Article
Language:English
Subjects:
Adducin
Alleles
Biomarkers
Confidence intervals
Gene polymorphism
Hypertension
Meta-analysis
Minority & ethnic groups
Polymorphism
Subgroups
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Huang, Yupeng
Yang, Guokang
description Background: Recently, the role of α‐adducin rs4961 polymorphism in hypertension (HTN) was intensively analyzed, but the results of these studies were inconsistent. Therefore, we performed this study to better assess the relationship between α‐adducin rs4961 polymorphism and the likelihood of HTN.Methods: Eligible studies were searched in PubMed, Medline, Embase, and Web of Science. Odds ratios with 95% confidence intervals were used to assess the relationship between α‐adducin rs4961 polymorphism and HTN.Results: A total of 33 studies with 40 432 participants were analyzed. Significant associations with the likelihood of HTN were detected for the α‐adducin rs4961 polymorphism with fixed effect models (FEM) (dominant model: P = 0.003; allele model: P = 0.003), but not with random effect models (REM). Further subgroup analysis according to ethnicity of participants revealed that the α‐adducin rs4961 polymorphism was significantly associated with the likelihood of HTN in Asians (7721 cases and 8299 controls) with both FEMs (dominant model: P 
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Therefore, we performed this study to better assess the relationship between α‐adducin rs4961 polymorphism and the likelihood of HTN.Methods: Eligible studies were searched in PubMed, Medline, Embase, and Web of Science. Odds ratios with 95% confidence intervals were used to assess the relationship between α‐adducin rs4961 polymorphism and HTN.Results: A total of 33 studies with 40 432 participants were analyzed. Significant associations with the likelihood of HTN were detected for the α‐adducin rs4961 polymorphism with fixed effect models (FEM) (dominant model: P = 0.003; allele model: P = 0.003), but not with random effect models (REM). Further subgroup analysis according to ethnicity of participants revealed that the α‐adducin rs4961 polymorphism was significantly associated with the likelihood of HTN in Asians (7721 cases and 8299 controls) with both FEMs (dominant model: P &lt; 0.0001; additive model: P = 0.01; allele model: P &lt; 0.0001) and REMs (dominant model: P = 0.0005; additive model: P = 0.03; allele model: P = 0.0006).Conclusions: Our findings indicate that the α‐adducin rs4961 polymorphism may serve as a genetic biomarker of HTN in Asians.</description><identifier>ISSN: 0730-2312</identifier><identifier>EISSN: 1097-4644</identifier><identifier>DOI: 10.1002/jcb.27749</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc</publisher><subject>Adducin ; Alleles ; Biomarkers ; Confidence intervals ; Gene polymorphism ; Hypertension ; Meta-analysis ; Minority &amp; ethnic groups ; Polymorphism ; Subgroups</subject><ispartof>Journal of cellular biochemistry, 2019-03, Vol.120 (3), p.4613-4619</ispartof><rights>2019 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>Jin, Hongyan</creatorcontrib><creatorcontrib>Huang, Yupeng</creatorcontrib><creatorcontrib>Yang, Guokang</creatorcontrib><title>Association between α‐adducin rs4961 polymorphism and hypertension: A meta‐analysis based on 40432 subjects</title><title>Journal of cellular biochemistry</title><description>Background: Recently, the role of α‐adducin rs4961 polymorphism in hypertension (HTN) was intensively analyzed, but the results of these studies were inconsistent. Therefore, we performed this study to better assess the relationship between α‐adducin rs4961 polymorphism and the likelihood of HTN.Methods: Eligible studies were searched in PubMed, Medline, Embase, and Web of Science. Odds ratios with 95% confidence intervals were used to assess the relationship between α‐adducin rs4961 polymorphism and HTN.Results: A total of 33 studies with 40 432 participants were analyzed. Significant associations with the likelihood of HTN were detected for the α‐adducin rs4961 polymorphism with fixed effect models (FEM) (dominant model: P = 0.003; allele model: P = 0.003), but not with random effect models (REM). Further subgroup analysis according to ethnicity of participants revealed that the α‐adducin rs4961 polymorphism was significantly associated with the likelihood of HTN in Asians (7721 cases and 8299 controls) with both FEMs (dominant model: P &lt; 0.0001; additive model: P = 0.01; allele model: P &lt; 0.0001) and REMs (dominant model: P = 0.0005; additive model: P = 0.03; allele model: P = 0.0006).Conclusions: Our findings indicate that the α‐adducin rs4961 polymorphism may serve as a genetic biomarker of HTN in Asians.</description><subject>Adducin</subject><subject>Alleles</subject><subject>Biomarkers</subject><subject>Confidence intervals</subject><subject>Gene polymorphism</subject><subject>Hypertension</subject><subject>Meta-analysis</subject><subject>Minority &amp; ethnic groups</subject><subject>Polymorphism</subject><subject>Subgroups</subject><issn>0730-2312</issn><issn>1097-4644</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNqNjMtNxDAUAC0EEuFzoIMncc7y_NlY5rZCIArY-8pJjNZRYhs_Ryg3SqAVGqEIKiFIFMBpLjPD2A3HDUcUd0PXboTWypywiqPRtWqUOmUVaom1kFycswuiARGNkaJiaUcUO2-LjwFaV96cC_D1-f3-Yft-7nyATMo0HFIclynmdPQ0gQ09HJfkcnGB1vIedjC5Yn-zYMeFPEFryfWwXhUqKYDmdnBdoSt29mJHctd_vGS3T4_7h-c65fg6OyqHIc55ndBB8EbjdssFyv9ZPzMmUZI</recordid><startdate>20190301</startdate><enddate>20190301</enddate><creator>Jin, Hongyan</creator><creator>Huang, Yupeng</creator><creator>Yang, Guokang</creator><general>Wiley Subscription Services, Inc</general><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope></search><sort><creationdate>20190301</creationdate><title>Association between α‐adducin rs4961 polymorphism and hypertension: A meta‐analysis based on 40432 subjects</title><author>Jin, Hongyan ; Huang, Yupeng ; Yang, Guokang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_journals_21670551203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adducin</topic><topic>Alleles</topic><topic>Biomarkers</topic><topic>Confidence intervals</topic><topic>Gene polymorphism</topic><topic>Hypertension</topic><topic>Meta-analysis</topic><topic>Minority &amp; ethnic groups</topic><topic>Polymorphism</topic><topic>Subgroups</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jin, Hongyan</creatorcontrib><creatorcontrib>Huang, Yupeng</creatorcontrib><creatorcontrib>Yang, Guokang</creatorcontrib><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Journal of cellular biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jin, Hongyan</au><au>Huang, Yupeng</au><au>Yang, Guokang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between α‐adducin rs4961 polymorphism and hypertension: A meta‐analysis based on 40432 subjects</atitle><jtitle>Journal of cellular biochemistry</jtitle><date>2019-03-01</date><risdate>2019</risdate><volume>120</volume><issue>3</issue><spage>4613</spage><epage>4619</epage><pages>4613-4619</pages><issn>0730-2312</issn><eissn>1097-4644</eissn><abstract>Background: Recently, the role of α‐adducin rs4961 polymorphism in hypertension (HTN) was intensively analyzed, but the results of these studies were inconsistent. Therefore, we performed this study to better assess the relationship between α‐adducin rs4961 polymorphism and the likelihood of HTN.Methods: Eligible studies were searched in PubMed, Medline, Embase, and Web of Science. Odds ratios with 95% confidence intervals were used to assess the relationship between α‐adducin rs4961 polymorphism and HTN.Results: A total of 33 studies with 40 432 participants were analyzed. Significant associations with the likelihood of HTN were detected for the α‐adducin rs4961 polymorphism with fixed effect models (FEM) (dominant model: P = 0.003; allele model: P = 0.003), but not with random effect models (REM). Further subgroup analysis according to ethnicity of participants revealed that the α‐adducin rs4961 polymorphism was significantly associated with the likelihood of HTN in Asians (7721 cases and 8299 controls) with both FEMs (dominant model: P &lt; 0.0001; additive model: P = 0.01; allele model: P &lt; 0.0001) and REMs (dominant model: P = 0.0005; additive model: P = 0.03; allele model: P = 0.0006).Conclusions: Our findings indicate that the α‐adducin rs4961 polymorphism may serve as a genetic biomarker of HTN in Asians.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc</pub><doi>10.1002/jcb.27749</doi></addata></record>
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subjects Adducin
Alleles
Biomarkers
Confidence intervals
Gene polymorphism
Hypertension
Meta-analysis
Minority & ethnic groups
Polymorphism
Subgroups
title Association between α‐adducin rs4961 polymorphism and hypertension: A meta‐analysis based on 40432 subjects
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