Electrochemical detection of an antibiotic drug chloramphenicol based on a graphene oxide/hierarchical zinc oxide nanocomposite

A novel electrochemical sensor based on a graphene oxide (GO)/three-dimensional (3D) hierarchical zinc oxide (ZnO) nanocomposite was developed for the efficient determination of the antibiotic drug chloramphenicol (CAP). The hierarchical ZnO structure consisting of nanosheets was synthesized by a gr...

Full description

Saved in:
Bibliographic Details
Published in:Inorganic chemistry frontiers 2019-01, Vol.6 (1), p.82-93
Main Authors: Neethu Sebastian, Wan-Chin, Yu, Deepak Balram
Format: Article
Language:English
Subjects:
Antibiotics
Aqueous solutions
Chemical sensors
Chloromycetin
Electrochemical analysis
Electrons
Fourier transforms
Glassy carbon
Graphene
Infrared spectroscopy
Inorganic chemistry
Mapping
Nanocomposites
Nanomaterials
Raman spectroscopy
Reproducibility
Scanning electron microscopy
Spectrum analysis
Structural hierarchy
Synthesis
Voltammetry
X-ray diffraction
Zinc oxide
Zinc oxides
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A novel electrochemical sensor based on a graphene oxide (GO)/three-dimensional (3D) hierarchical zinc oxide (ZnO) nanocomposite was developed for the efficient determination of the antibiotic drug chloramphenicol (CAP). The hierarchical ZnO structure consisting of nanosheets was synthesized by a green aqueous solution procedure and then composited with GO through a simple sonochemical method. The synthesized ZnO and GO/ZnO nanomaterials were characterized by scanning electron microscopy (SEM), elemental mapping, X-ray diffraction (XRD), UV-Visible spectroscopy, Fourier transform infrared spectroscopy (FT-IR), and Raman spectroscopy. The electrochemical performance of the prepared GO/ZnO/glassy carbon electrode (GCE) was evaluated using cyclic voltammetry (CV) and differential pulse voltammetry (DPV) techniques. The GO/ZnO/GCE shows a low CAP detection limit of 0.01 μM, a high sensitivity of 7.27 μA μM−1 cm−2, and a linear response in the range of 0.2 to 7.2 μM. Moreover, it exhibits excellent stability, reproducibility and repeatability. Practicality of the sensor has further been demonstrated with honey, milk and eye drop samples.
ISSN:2052-1545
2052-1553
DOI:10.1039/c8qi01000e