HLA-Cw7 zygosity affects the size of a subset of CD158b^sup +^ natural killer cells

Individuals with certain HLA class I genotypes are highly susceptible to disease after viral infection. Natural killer (NK) cells kill virus-infected cells through a mechanism involving HLA class I receptors. These facts may be connected if an individual's HLA genotype regulates the number and...

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Bibliographic Details
Published in:Journal of clinical immunology 2002-01, Vol.22 (1), p.28
Main Authors: Husain, Zaheed, Levitan, Edward, Larsen, Charles E, Mirza, Nadeem M
Format: Article
Language:English
Online Access:Get full text
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Summary:Individuals with certain HLA class I genotypes are highly susceptible to disease after viral infection. Natural killer (NK) cells kill virus-infected cells through a mechanism involving HLA class I receptors. These facts may be connected if an individual's HLA genotype regulates the number and function of NK cells. We have observed that subjects homozygous for the HLA-B/C region of conserved major histocompatibility complex (MHC) extended haplotypes have lower NK cell activity and a significantly lower frequency of CD16+CD56+ NK cells than heterozygotes. The proportion of CD16-CD56+ NK cells was unaffected by zygosity for the HLA-B/C region. We show here that the frequency of CD16+CD158b+, but not CD16-CD158b+ NK cells, was significantly lower (p
ISSN:0271-9142
1573-2592