Engineering Sensor Arrays Using Aggregation‐Induced Emission Luminogens for Pathogen Identification

• Published in: Advanced functional materials 2019-01, Vol.29 (4), p.n/a
• Main Authors: Zhou, Chengcheng, Xu, Wenhan, Zhang, Pengbo, Jiang, Meijuan, Chen, Yuncong, Kwok, Ryan T. K., Lee, Michelle M. S., Shan, Guogang, Qi, Ruilian, Zhou, Xin, Lam, Jacky W. Y., Wang, Shu, Tang, Ben Zhong
• Format: Article
• Language: English
• Subjects: Agglomeration; AIEgens; Antibiotics; Diagnostic systems; Emission; Fluorescence; Materials science; mathematical analysis; multivalent interaction; pathogen detection; Pathogens; Sensor arrays; Sensors; simple and accurate
• ISSN: 1616-301X; 1616-3028
• DOI: 10.1002/adfm.201805986

Lacking rapid and reliable pathogen diagnostic platforms, inadequate or delayed antimicrobial therapy could be made, which greatly threatens human life and accelerates the emergence of antibiotic‐resistant pathogens. In this contribution, a series of simple and reliable sensor arrays based on tetraphenylethylene (TPE) derivatives are successfully developed for detection and discrimination of pathogens. Each sensor array consists of three TPE‐based aggregation‐induced emission luminogens (AIEgens) that bear cationic ammonium group and different hydrophobic substitutions, providing tunable logP (n‐octanol/water partition coefficient) values to enable the different multivalent interactions with pathogens. On the basis of the distinctive fluorescence response produced by the diverse interaction of AIEgens with pathogens, these sensor arrays can identify different kinds of pathogens, even normal and drug‐resistant bacteria, with nearly 100% accuracy. Furthermore, blends of pathogens can also be identified accurately. The sensor arrays exhibit rapid response (about 0.5 h), high‐throughput, and easy‐to‐operate without washing steps. A series of simple and reliable sensor arrays based on aggregation‐induced emission (AIE)‐active tetraphenylethylene derivatives are successfully developed for fast and accurate pathogen identification. Based on the distinctive fluorescence response produced by the multivalent interaction of AIE luminogens with pathogens, these sensor arrays can identify different pathogens, even normal and drug‐resistant bacteria, with nearly 100% accuracy.