Euryale Ferox Seed‐Inspired Superlubricated Nanoparticles for Treatment of Osteoarthritis

Osteoarthritis has been regarded as a typical lubrication deficiency related joint disease, which is characterized by the breakdown of articular cartilage at the joint surface and the inflammation of the joint capsule. Here, inspired by the structure of the fresh euryale ferox seed that possesses a...

Full description

Saved in:
Bibliographic Details
Published in:Advanced functional materials 2019-01, Vol.29 (4), p.n/a
Main Authors: Yan, Yufei, Sun, Tao, Zhang, Hongbo, Ji, Xiuling, Sun, Yulong, Zhao, Xin, Deng, Lianfu, Qi, Jin, Cui, Wenguo, Santos, Hélder A., Zhang, Hongyu
Format: Article
Language:English
Subjects:
Arthritis
Biocompatibility
bioinspired
Biomedical materials
Cartilage
Degeneration
Diclofenac
Drug delivery systems
Lubrication
Materials science
Nanoparticles
osteoarthritis
Photopolymerization
Polyelectrolytes
Potassium salts
Silicon dioxide
Thickness
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Osteoarthritis has been regarded as a typical lubrication deficiency related joint disease, which is characterized by the breakdown of articular cartilage at the joint surface and the inflammation of the joint capsule. Here, inspired by the structure of the fresh euryale ferox seed that possesses a slippery aril and a hard coat containing starchy kernel, a novel superlubricated nanoparticle, namely poly (3‐sulfopropyl methacrylate potassium salt)‐grafted mesoporous silica nanoparticles (MSNs‐NH2@PSPMK), is biomimicked and synthesized via a one‐step photopolymerization method. The nanoparticles are endowed with enhanced lubrication by the grafted PSPMK polyelectrolyte polymer due to the formation of tenacious hydration layers surrounding the negative charges, and simultaneously are featured with effective drug loading and release behavior as a result of the sufficient mesoporous channels in the MSNs. When encapsulated with an anti‐inflammatory drug diclofenac sodium (DS), the lubrication capability of the superlubricated nanoparticles is improved, while the drug release rate is sustained by increasing the thickness of PSPMK layer, which is simply achieved via adjustment of the precursor monomer concentration in the photopolymerization process. Additionally, the in vitro and in vivo experimental results show that the DS‐loaded MSNs‐NH2@PSPMK nanoparticles effectively protect the chondrocytes from degeneration, and thus, inhibit the development of osteoarthritis. Bioinspired by the unique structure of the fresh euryale ferox seed, a novel superlubricated drug‐loaded nanoparticle is designed and synthesized based on photopolymerization for the treatment of osteoarthritis.
ISSN:1616-301X
1616-3028
DOI:10.1002/adfm.201807559