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Preparation and Characterization of Taxifolin FormII by Antisolvent Recrystallization
To improve the aqueous solubility and dissolution rate of taxifolin, taxifolin form II was successfully prepared through antisolvent recrystallization, in which 1‐butyl‐3‐methylimidazolium tetrafluoroborate and dichloromethane were used as solvent and antisolvent, respectively. The properties of tax...
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| Published in: | Chemical engineering & technology 2019-02, Vol.42 (2), p.414-421 |
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| Main Authors: | , , , , , , |
| Format: | Article |
| Language: | English |
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| container_end_page | 421 |
| container_issue | 2 |
| container_start_page | 414 |
| container_title | Chemical engineering & technology |
| container_volume | 42 |
| creator | Wu, Weiwei Wang, Lingling Wang, Li Zu, Yuangang Wang, Lu Zhang, Yin Zhao, Xiuhua |
| description | To improve the aqueous solubility and dissolution rate of taxifolin, taxifolin form II was successfully prepared through antisolvent recrystallization, in which 1‐butyl‐3‐methylimidazolium tetrafluoroborate and dichloromethane were used as solvent and antisolvent, respectively. The properties of taxifolin form II were characterized by scanning electron microscopy, Fourier transform infrared spectroscopy, X‐ray diffraction, differential scanning calorimetry, solid‐state NMR spectroscopy, the dissolving capability test, and the bioavailability test. The chemical structure of taxifolin form II was not changed, but its morphology and crystalline structure changed during the recrystallization process. Moreover, taxifolin form II showed higher solubility, faster dissolution rate, and better bioavailability than taxifolin form I. |
| doi_str_mv | 10.1002/ceat.201800339 |
| format | article |
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The properties of taxifolin form II were characterized by scanning electron microscopy, Fourier transform infrared spectroscopy, X‐ray diffraction, differential scanning calorimetry, solid‐state NMR spectroscopy, the dissolving capability test, and the bioavailability test. The chemical structure of taxifolin form II was not changed, but its morphology and crystalline structure changed during the recrystallization process. Moreover, taxifolin form II showed higher solubility, faster dissolution rate, and better bioavailability than taxifolin form I.</description><identifier>ISSN: 0930-7516</identifier><identifier>EISSN: 1521-4125</identifier><identifier>DOI: 10.1002/ceat.201800339</identifier><language>eng</language><publisher>Frankfurt: Wiley Subscription Services, Inc</publisher><subject>Bioavailability ; Dichloromethane ; Dissolution ; Fourier transforms ; Morphology ; NMR spectroscopy ; Organic chemistry ; Recrystallization ; Scanning electron microscopy ; Solubility ; Spectrum analysis ; X-ray diffraction</subject><ispartof>Chemical engineering & technology, 2019-02, Vol.42 (2), p.414-421</ispartof><rights>2019 WILEY‐VCH Verlag GmbH & Co. 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The properties of taxifolin form II were characterized by scanning electron microscopy, Fourier transform infrared spectroscopy, X‐ray diffraction, differential scanning calorimetry, solid‐state NMR spectroscopy, the dissolving capability test, and the bioavailability test. The chemical structure of taxifolin form II was not changed, but its morphology and crystalline structure changed during the recrystallization process. Moreover, taxifolin form II showed higher solubility, faster dissolution rate, and better bioavailability than taxifolin form I.</description><subject>Bioavailability</subject><subject>Dichloromethane</subject><subject>Dissolution</subject><subject>Fourier transforms</subject><subject>Morphology</subject><subject>NMR spectroscopy</subject><subject>Organic chemistry</subject><subject>Recrystallization</subject><subject>Scanning electron microscopy</subject><subject>Solubility</subject><subject>Spectrum analysis</subject><subject>X-ray diffraction</subject><issn>0930-7516</issn><issn>1521-4125</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNqNi00PATEURRshMT621k2sh_faGcxShLATGWup0YlOqqUtwa83CT_A6ubccy8hA4QRArBxIUUYMcAZAOdZg0SYMowTZGmTRJBxiKcpTtqk430FAFhDRPZbJ6_CiaCsocKc6OJcUxGkU-9vaUuai6cqrVaGrqy7bDb0-KJzE5S3-iFNoDtZuJcPQuvfqUdapdBe9n_ZJcPVMl-s46uzt7v04VDZuzO1OjCcZJyxWcL5f6sPxW1ICA</recordid><startdate>20190201</startdate><enddate>20190201</enddate><creator>Wu, Weiwei</creator><creator>Wang, Lingling</creator><creator>Wang, Li</creator><creator>Zu, Yuangang</creator><creator>Wang, Lu</creator><creator>Zhang, Yin</creator><creator>Zhao, Xiuhua</creator><general>Wiley Subscription Services, Inc</general><scope>7U5</scope><scope>8FD</scope><scope>L7M</scope></search><sort><creationdate>20190201</creationdate><title>Preparation and Characterization of Taxifolin FormII by Antisolvent Recrystallization</title><author>Wu, Weiwei ; Wang, Lingling ; Wang, Li ; Zu, Yuangang ; Wang, Lu ; Zhang, Yin ; Zhao, Xiuhua</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_journals_21693228433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Bioavailability</topic><topic>Dichloromethane</topic><topic>Dissolution</topic><topic>Fourier transforms</topic><topic>Morphology</topic><topic>NMR spectroscopy</topic><topic>Organic chemistry</topic><topic>Recrystallization</topic><topic>Scanning electron microscopy</topic><topic>Solubility</topic><topic>Spectrum analysis</topic><topic>X-ray diffraction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, Weiwei</creatorcontrib><creatorcontrib>Wang, Lingling</creatorcontrib><creatorcontrib>Wang, Li</creatorcontrib><creatorcontrib>Zu, Yuangang</creatorcontrib><creatorcontrib>Wang, Lu</creatorcontrib><creatorcontrib>Zhang, Yin</creatorcontrib><creatorcontrib>Zhao, Xiuhua</creatorcontrib><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Chemical engineering & technology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Weiwei</au><au>Wang, Lingling</au><au>Wang, Li</au><au>Zu, Yuangang</au><au>Wang, Lu</au><au>Zhang, Yin</au><au>Zhao, Xiuhua</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preparation and Characterization of Taxifolin FormII by Antisolvent Recrystallization</atitle><jtitle>Chemical engineering & technology</jtitle><date>2019-02-01</date><risdate>2019</risdate><volume>42</volume><issue>2</issue><spage>414</spage><epage>421</epage><pages>414-421</pages><issn>0930-7516</issn><eissn>1521-4125</eissn><abstract>To improve the aqueous solubility and dissolution rate of taxifolin, taxifolin form II was successfully prepared through antisolvent recrystallization, in which 1‐butyl‐3‐methylimidazolium tetrafluoroborate and dichloromethane were used as solvent and antisolvent, respectively. 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| fulltext | fulltext |
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| ispartof | Chemical engineering & technology, 2019-02, Vol.42 (2), p.414-421 |
| issn | 0930-7516 1521-4125 |
| language | eng |
| recordid | cdi_proquest_journals_2169322843 |
| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Bioavailability Dichloromethane Dissolution Fourier transforms Morphology NMR spectroscopy Organic chemistry Recrystallization Scanning electron microscopy Solubility Spectrum analysis X-ray diffraction |
| title | Preparation and Characterization of Taxifolin FormII by Antisolvent Recrystallization |
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