Effects of herbal medicine for xerostomia in head and neck cancer patients: an observational study in a tertiary cancer hospital

• Published in: Supportive care in cancer 2019-09, Vol.27 (9), p.3491-3498
• Main Authors: Lim, Ren Jye, Nik Nabil, Wan Najbah, Chan, Si Yan, Wong, Yoke Fui, Han, Li Xian, Gong, Jia Ying, Ho, Kun Ling, Shew, Yee Siang, Xu, Li
• Format: Article
• Language: English
• Subjects: Analysis; Cancer; Cancer patients; Care and treatment; Cevimeline; Chinese medicine; Clinical trials; Development and progression; Eating behavior; Head & neck cancer; Head and neck cancer; Herbal medicine; Medicine; Medicine & Public Health; Medicine, Botanic; Medicine, Herbal; Nursing; Nursing Research; Observational studies; Oncology; Oncology, Experimental; Oral diseases; Original Article; Pain; Pain Medicine; Quality of life; Radiation therapy; Rehabilitation Medicine; Speech; Xerostomia
• ISSN: 0941-4355; 1433-7339
• DOI: 10.1007/s00520-019-4646-2

Purpose More than 80% head and neck cancer patients endured radiotherapy-induced xerostomia which impacts their quality of life (QoL). This observational study evaluated the effect of herbal treatment on head and neck cancer patients’ xerostomia and QoL. Methods Head and neck cancer patients were recruited from July 2016 till March 2017 at National Cancer Institute, Ministry of Health, Malaysia. All study participants continued their standard oncology surveillance. Treatment group participants additionally received Chinese herbal treatment. The assessments included unstimulated salivary flow rate (USFR), stimulated salivary flow rate (SSFR), and QoL questionnaire. Results Of 42 recruited participants, 28 were in the treatment group and 14 were in the control group. Participants were mainly Chinese (71.4%), stage III cancer (40.5%), and had nasopharynx cancer (76.2%). The commonly used single herbs were Wu Mei, San Qi, and Tian Hua Fen. Sha Shen Mai Dong Tang, Liu Wei Di Huang Wan, and Gan Lu Yin were the frequently prescribed herbal formulas. The baseline characteristics, USFR, SSFR, and QoL between control and treatment groups were comparable ( p  > 0.05). USFR between control and treatment groups were similar throughout the 6-month study period. SSFR for the treatment group significantly improved from 0.15 ± 0.28 ml/min (baseline) to 0.32 ± 0.22 ml/min ( p  = 0.04; at the 3rd month) and subsequently achieved 0.46 ± 0.23 ml/min ( p  = 0.001; at the 6th month). The treatment group had better QoL in terms of speech ( p  = 0.005), eating ( p  = 0.02), and head and neck pain ( p  = 0.04) at the 6th month. Conclusion Herbal treatment may improve xerostomia and QoL in post-radiotherapy head and cancer patients.