Prevalence of oral side effects of chemotherapy and its relationship with periodontal risk: a cross sectional study

Purpose To determine the prevalence of professionally reported oral side effects of chemotherapy and the self-reported oral side effects and whether both prevalences could be related to the periodontal risk of the patients. Methods A cross-sectional study with patients undergoing chemotherapy treatm...

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Bibliographic Details
Published in:Supportive care in cancer 2019-09, Vol.27 (9), p.3479-3490
Main Authors: García-Chías, B., Figuero, E., Castelo-Fernández, B., Cebrián-Carretero, J. L., Cerero-Lapiedra, R.
Format: Article
Language:English
Subjects:
Cancer
Cancer therapies
Care and treatment
Chemotherapy
Cross-sectional studies
Development and progression
Health aspects
Hospital patients
Medical research
Medicine
Medicine & Public Health
Medicine, Experimental
Nursing
Nursing Research
Oncology
Oral diseases
Oral hygiene
Original Article
Pain Medicine
Patients
Rehabilitation Medicine
Side effects
Toiletries industry
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Summary:Purpose To determine the prevalence of professionally reported oral side effects of chemotherapy and the self-reported oral side effects and whether both prevalences could be related to the periodontal risk of the patients. Methods A cross-sectional study with patients undergoing chemotherapy treatment was carried out. Demographic, oral hygiene habits, and cancer-related data were collected while the patient was receiving the chemotherapy infusion. Patient’s oral status, measured according to the oral-assessment guide for patients in hospital environments, patient-related outcomes (PROMs), measured by a visual analogue scale, and patient’s periodontal risk were analyzed using validated questionnaires. Data was reported in means and standard deviations (SD) in quantitative variables and in counts, prevalence, and 95% confidence intervals (CI) in qualitative variables. ANOVA test and chi-squared tests were used to compare oral side effects among different periodontal risk groups. Results Three hundred sixty-nine patients were included in the study. The prevalence of professionally reported oral side effects was 86.99% (95% confidence interval CI 83.54%; 90.44%). The prevalence of self-reported oral side effects was 89.70% (95% CI 86.59; 92.82). The most common oral side effects were xerostomia (73.4%), dysgeusia (61.8%), and dry lips (54.2%). More oral alterations were found in patients with worse periodontal risk ( p  
ISSN:0941-4355
1433-7339
DOI:10.1007/s00520-019-4650-6