An evaluation of pre- and postoperative nonsteroidal antiinflammatory drugs in patients undergoing knee arthroscopy

• Published in: The American journal of sports medicine 1993-07, Vol.21 (4), p.510
• Main Authors: Nelson, William E, Henderson, Richard C, Almekinders, Louis C, DeMasi, Ralph A, Taft, Timothy N
• Format: Article
• Language: English
• Subjects: Drugs; Knee; Sports medicine; Surgery
• ISSN: 0363-5465; 1552-3365
• DOI: 10.1177/036354659302100406

The potential benefits of a nonsteroidal antiinflamma tory drug to 67 patients undergoing knee arthroscopy were evaluated in a prospective, randomized, placebo- controlled, double-blinded study. Group A received the drug (diclofenac, 75 mg twice daily) for 3 to 5 days before and for 7 days after surgery. Group B received a placebo preoperatively and the drug postoperatively. Group C received a placebo at both times. Codeine was available postoperatively for all patients if needed. Outcomes reported by the subjects included pain, crutch use, and return to activities. Outcomes assessed by physicians included knee effusion, range of motion, and gait. Knee flexion and extension strengths were measured isokinetically pre- and postoperatively. Pain scores on the 1 st postoperative day were higher in Group C than in Group A. Pain scores at all other time points were not significantly different in the three treatment groups. Groups A and B required less co deine during the first 72 hours after surgery than Group C (mean, 2.9 ± 1.0 versus 6.8 ± 1.0 pills). Recovery of function, recovery of strength, and physical examina tion parameters were not significantly different in the three treatment groups. Diclofenac was an effective analgesic in the immedi ate postoperative period. Recovery from arthroscopy, however, was not enhanced by taking the drug.