An assessment of health status among medical research volunteers who served in the Project Whitecoat program at Fort Detrick, Maryland

Between 1954 and 1973, more than 2000 men entering military service as conscientious objectors participated in Project Whitecoat as medical research volunteers for the Army's biological warfare defense program. An assessment of self-reported, current health status among 358 "exposed"...

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Bibliographic Details
Published in:Military medicine 2005-03, Vol.170 (3), p.183-187
Main Authors: Pittman, Phillip R, Norris, Sarah L, Coonan, Kevin M, McKee, Jr, Kelly T
Format: Article
Language:English
Subjects:
Aged
Biological Warfare - history
Cohort Studies
Communicable Diseases - physiopathology
Conscience
Health Behavior
Health Status
History, 20th Century
Human Experimentation
Humans
Male
Maryland
Middle Aged
Military Medicine - history
Military Personnel
Occupational Exposure
Program Evaluation
Retrospective Studies
Vaccines
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Summary:Between 1954 and 1973, more than 2000 men entering military service as conscientious objectors participated in Project Whitecoat as medical research volunteers for the Army's biological warfare defense program. An assessment of self-reported, current health status among 358 "exposed" individuals and 164 unexposed control subjects found no conclusive evidence that receipt of investigational agents was related to adverse health outcomes. No differences in current overall health, current exercise levels, self-reported symptoms, and self-reported medical conditions were seen between the study groups. Possible associations were seen between exposure to antibiotics or other biological agents and self-reported asthma (13.0% vs. 2.4%, relative risk [RR] = 6.00, 95% confidence interval [CI] = 1.03-34.90, p = 0.050), as well as between receipt of tularemia vaccine(s) and self-reported asthma (13.3% vs. 2.4%, RR = 6.15, 95% CI = 1.03-36.70, p = 0.049) and increased frequency/severity of headaches (35.6% vs. 18.3%, RR = 2.46, 95% CI = 0.99-6.15, p = 0.074). However, the size of the population under study was insufficient to assert with confidence that these statistical associations are real.
ISSN:0026-4075
1930-613X
DOI:10.7205/MILMED.170.3.183