Bench‐Stable Cobalt Pre‐Catalysts for Mild Hydrosilative Reduction of Tertiary Amides to Amines and Beyond

The readily synthesized and bench‐stable cobalt dichloride complex (dpephos)CoCl2 is employed as a pre‐catalyst for a diversity of silane additions to unsaturated organic molecules, including the normally challenging reduction of amides to amines. With regard to hydrosilative reduction of amides eve...

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Bibliographic Details
Published in:ChemCatChem 2019-01, Vol.11 (2), p.790-798
Main Authors: Nurseiit, Alibek, Janabel, Jaysan, Gudun, Kristina A., Kassymbek, Aishabibi, Segizbayev, Medet, Seilkhanov, Tulegen M., Khalimon, Andrey Y.
Format: Article
Language:English
Subjects:
Amides
Amines
Catalysis
Catalysts
Cobalt
Dichlorides
homogeneous catalysis
Hydrosilylation
Organic chemistry
Reduction
System effectiveness
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Summary:The readily synthesized and bench‐stable cobalt dichloride complex (dpephos)CoCl2 is employed as a pre‐catalyst for a diversity of silane additions to unsaturated organic molecules, including the normally challenging reduction of amides to amines. With regard to hydrosilative reduction of amides even more effective and activator free catalytic systems can be generated from the bench‐stable, commercially available Co(acac)2 and Co(OAc)2 with dpephos and PPh3 ligands. These systems operate under mild conditions (
ISSN:1867-3880
1867-3899
DOI:10.1002/cctc.201801605