PKCalpha regulates the hypertrophic growth of cardiomyocytes through extracellular signal-regulated kinase 1/2 (ERK1/2)

Within the heart, protein kinase C (PKC) isozymes are thought to participate in a signaling network that programs developmental and pathological cardiomyocyte hypertrophic growth. To investigate the function of PKC signaling in regulating cardiomyocyte growth, adenoviral-mediated gene transfer of wi...

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Bibliographic Details
Published in:The Journal of cell biology 2002-03, Vol.156 (5), p.905
Main Authors: Braz, Julian C, Bueno, Orlando F, De Windt, Leon J, Molkentin, Jeffery D
Format: Article
Language:English
Subjects:
Cells
Cellular biology
Heart
Proteins
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Summary:Within the heart, protein kinase C (PKC) isozymes are thought to participate in a signaling network that programs developmental and pathological cardiomyocyte hypertrophic growth. To investigate the function of PKC signaling in regulating cardiomyocyte growth, adenoviral-mediated gene transfer of wild-type and dominant negative mutants of PKCalpha, betaII, delta, and epsilon was performed in cultured neonatal rat cardiomyocytes.
ISSN:0021-9525
1540-8140