Mediation of growth factor induced DNA synthesis and calcium mobilization by G(q) and G(i2)

The potential role of the protein Gq in growth factor signal transduction pathways and its potential relationship to the function of other G alpha subclasses were examined. It was determined that G alpha q transduces bradykinin- and thrombin-stimulated intracellular calcium transients that are likel...

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Bibliographic Details
Published in:The Journal of cell biology 1993-04, Vol.121 (1), p.91
Main Authors: LaMorte, V J, Harootunian, A T, Spiegel, A M, Tsien, R Y, Feramisco, J R
Format: Article
Language:English
Subjects:
Calcium
Cellular biology
Proteins
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Summary:The potential role of the protein Gq in growth factor signal transduction pathways and its potential relationship to the function of other G alpha subclasses were examined. It was determined that G alpha q transduces bradykinin- and thrombin-stimulated intracellular calcium transients that are likely to be mediated by PLC beta 1.
ISSN:0021-9525
1540-8140
DOI:10.1083/jcb.121.1.91