Requirement of the Integrin (beta)3 Subunit for Carcinoma Cell Spreading or Migration on Vitronectin and Fibrinogen

FG cells expressing beta3 acquire the capacity to attach and spread on vitronectin as well as fibrinogen with beta3 localization to focal contacts. The beta3 and beta5 integrin subunits, when associated with alphav, promote distinct responses to a vitronectin extracellular environment.

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Bibliographic Details
Published in:The Journal of cell biology 1992-06, Vol.117 (5), p.1101
Main Authors: Leavesley, D I, Ferguson, G D
Format: Article
Language:English
Subjects:
Cellular biology
Medical research
Online Access:Get full text
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Description
Summary:FG cells expressing beta3 acquire the capacity to attach and spread on vitronectin as well as fibrinogen with beta3 localization to focal contacts. The beta3 and beta5 integrin subunits, when associated with alphav, promote distinct responses to a vitronectin extracellular environment.
ISSN:0021-9525
1540-8140