Repetitious appearance and disappearance of different kinds of clonal cytogenetic abnormalities after allogeneic bone marrow transplantation

We report a childhood case that showed the repeated appearance and disappearance of various kinds of cytogenetic abnormalities (CA) for 5.5 years after allogeneic bone marrow transplantation (BMT). The patient underwent allogeneic BMT from an HLA-matched unrelated donor during the second complete re...

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Bibliographic Details
Published in:International journal of hematology 2001-07, Vol.74 (1), p.86-89
Main Authors: LIN, Ying-Wei, HAMAHATA, Keigo, WATANABE, Ken-Ichiro, ADACHI, Souichi, AKIYAMA, Yuichi, KUBOTA, Masaru, NAKAHATA, Tatsutoshi
Format: Article
Language:English
Subjects:
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Asparaginase - administration & dosage
Biological and medical sciences
Bone marrow
Bone Marrow Transplantation
Child, Preschool
Chromosome Aberrations
Chromosome Disorders
Clone Cells - drug effects
Clone Cells - radiation effects
Clone Cells - ultrastructure
Combined Modality Therapy
Cyclophosphamide - administration & dosage
Cytarabine - administration & dosage
Daunorubicin - administration & dosage
DNA Damage
Female
Follow-Up Studies
Hematologic and hematopoietic diseases
Humans
In Situ Hybridization, Fluorescence
Karyotyping
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Medical sciences
Mercaptopurine - administration & dosage
Methotrexate - administration & dosage
Methylprednisolone - administration & dosage
Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics
Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy
Prednisolone - administration & dosage
Remission Induction
Time Factors
Transplantation Conditioning
Transplantation, Homologous
Transplants & implants
Vincristine - administration & dosage
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Summary:We report a childhood case that showed the repeated appearance and disappearance of various kinds of cytogenetic abnormalities (CA) for 5.5 years after allogeneic bone marrow transplantation (BMT). The patient underwent allogeneic BMT from an HLA-matched unrelated donor during the second complete remission of acute lymphoblastic leukemia. The conditioning regimen for BMT consisted of etoposide, cyclophosphamide, anti-human thymocyte immunoglobulin, and total body irradiation. There were no leukemic relapses or secondary acute myeloid leukemia/myelodysplastic syndrome (AML/MDS) since the BMT. The CA occurred from residual recipient cells, which were damaged by chemotherapy or radiation prior to BMT. Although previous studies about post-BMT CA had reported the continuous emergence of identical clones, the present case showed the appearance of one different type of clone after another. Although the appearance of different types of CA may mean that these clones did not obtain any growth advantages, it may be a sign of genomic instability, which is probably a risk factor for the development of secondary AML/MDS.
ISSN:0925-5710
1865-3774
DOI:10.1007/BF02982555