Successful treatment of nasal T-cell lymphoma with a combination of local irradiation and high-dose chemotherapy

Nasal natural killer (NK)/T-cell lymphoma is characterized by an aggressive clinical course and poor prognosis. The term "NK/T-cell" lymphoma includes both the NK-cell type and the T-cell type, which are classified by immunophenotyping and according to T-cell receptor (TCR) rearrangement....

Full description

Saved in:
Bibliographic Details
Published in:International journal of hematology 2002-02, Vol.75 (2), p.195-200
Main Authors: SANDA, Takaomi, IIDA, Shinsuke, ITO, Masato, TSUBOI, Kazuya, MIURA, Kazuhisa, HARADA, Shinsuke, KOMATSU, Hirokazu, WAKITA, Atsushi, INAGAKI, Hiroshi, UEDA, Ryuzo
Format: Article
Language:English
Subjects:
Antineoplastic agents
Antineoplastic Combined Chemotherapy Protocols - administration & dosage
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Biological and medical sciences
Combined Modality Therapy
Combined treatments (chemotherapy of immunotherapy associated with an other treatment)
Cyclophosphamide - administration & dosage
Doxorubicin - administration & dosage
Female
Hematologic and hematopoietic diseases
Humans
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Lymphoma, T-Cell - therapy
Medical sciences
Middle Aged
Nose Neoplasms - therapy
Pharmacology. Drug treatments
Prednisolone - administration & dosage
Radiotherapy, Adjuvant
Remission Induction
Stem Cell Transplantation
Transplantation, Autologous
Vincristine - administration & dosage
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Nasal natural killer (NK)/T-cell lymphoma is characterized by an aggressive clinical course and poor prognosis. The term "NK/T-cell" lymphoma includes both the NK-cell type and the T-cell type, which are classified by immunophenotyping and according to T-cell receptor (TCR) rearrangement. In addition, CD56+ T-cell lymphoma is defined as NK-like T-cell lymphoma. This report concerns a 54-year-old woman with nasal T-cell lymphoma. Its phenotype showed pure T-cell type with CD3+, CD56-, and TCR+ accompanied by Epstein-Barr virus infection. Although the lesions were localized in the nasal mucosa and facial skin (stage IE), local irradiation could not achieve complete remission (CR). We then administered 5 courses of CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisolone) regimen followed by high-dose chemotherapy with an autologous peripheral blood stem cell transplantation. This therapy resulted in CR. Our results suggest that this lymphoma subtype may be cured by means of intensive treatment soon after diagnosis.
ISSN:0925-5710
1865-3774
DOI:10.1007/BF02982028