Case of chronic lymphocytic leukemia with unusual chromosome aberrations

Chronic lymphocytic leukemia is one of the most common leukemias in the western world and consists of many chromosome aberrations. We report the case of a 74-year-old male patient with chronic lymphocytic leukemia with complex variant translocations t(8;22)(q24;q11) and der(8)t(6;8)(p21;p21) identif...

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Bibliographic Details
Published in:International journal of hematology 2004-11, Vol.80 (4), p.351-353
Main Authors: HSIAO, Hui-Hua, HUNG, Yi-Hui, HSIAO, Hui-Pin, TSENG, Shih-Bin, TSAI, Hui-Jen, LIU, Yi-Chang, LIU, Ta-Chih, CHAO, Mei-Chyn, YULI CHANG, LIN, Sheng-Fung
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Chromosomes, Human, Pair 22
Chromosomes, Human, Pair 6
Chromosomes, Human, Pair 8
Fatal Outcome
Hematologic and hematopoietic diseases
Humans
Leukemia, Lymphocytic, Chronic, B-Cell - genetics
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Male
Medical sciences
Translocation, Genetic
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Summary:Chronic lymphocytic leukemia is one of the most common leukemias in the western world and consists of many chromosome aberrations. We report the case of a 74-year-old male patient with chronic lymphocytic leukemia with complex variant translocations t(8;22)(q24;q11) and der(8)t(6;8)(p21;p21) identified by chromosome banding analysis and confirmed by fluorescence in situ hybridization analysis of interphase cells. Because of the rarity of these changes, possible molecular mechanisms associated with this karyotype are discussed.
ISSN:0925-5710
1865-3774
DOI:10.1532/IJH97.A10323