Tri‐Functional Elemental Sulfur Enabling Bis‐Heteroannulation of Methyl Ketoximes with Methyl N‐Heteroarenes

• Published in: Advanced synthesis & catalysis 2019-02, Vol.361 (3), p.591-596
• Main Authors: Huang, Huawen, Wang, Qian, Xu, Zhenhua, Deng, Guo‐Jun
• Format: Article
• Language: English
• Subjects: A concise transition metal-free approach to the fused thieno[3,2-d]thiazoles from methyl ketoximes, methyl N-heteroarenes, and elemental sulfur under basic reaction conditions is described. In this protocol, elemental sulfur plays three functions: (a) oxidative activation of methyl N-heteroarenes, (b) reductive activation of methyl oxime acetates, and (c) as a viable sulfur source to provide two sulfur atoms. The robust nature of the reaction further reflected by the broad substrate scope and gram-scale synthesis; bis-heteroannulation; Chemical reactions; elemental sulfur; ketone oximes; methyl N-heteroarenes; Organic chemistry; transition-metal-free
• ISSN: 1615-4150; 1615-4169
• DOI: 10.1002/adsc.201801324

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