Levels of Hippocampal, Liver, and Plasma Insulin-like Growth Factor 1 (IGF-1) in Male Adult Rats Treated with Combination of Aerobic Exercise and Continuous Environmental Enrichment

The purpose of this study was to determine the effect of the combination treatment of both aerobic exercise and environmental enrichment (EE) on the levels of hippocampal, liver, and plasma Insulin-like growth factor 1 (IGF- 1). IGF-1 has been recently shown to play a role in neuroplasticity includi...

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Published in:Journal of exercise physiology online 2019-02, Vol.22 (1), p.11
Main Authors: Yolanda, Sophie, Mailani, Rena, Prasetyo, Sri Redjeki, Widyani, Ni Made Sarastri, Juffry, Sarah Kamiela
Format: Article
Language:English
Subjects:
Aerobics
Exercise
Insulin-like growth factors
Physical fitness
Rodents
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Summary:The purpose of this study was to determine the effect of the combination treatment of both aerobic exercise and environmental enrichment (EE) on the levels of hippocampal, liver, and plasma Insulin-like growth factor 1 (IGF- 1). IGF-1 has been recently shown to play a role in neuroplasticity including memory function. Both aerobic exercise and EE on their own have been proven to increase neuroplasticity. Twenty 7-month-old male Wistar rats were divided randomly into 4 groups: (a) control (C); (b) aerobic (A); (c) environmental enrichment (EE); and (d) combination of aerobic exercise and EE (A-EE) for 8 wks. There were no significant differences in the plasma and hippocampal IGF-1 levels between the groups (P = 0.65 and P = 0.13, respectively). There were significant differences in the liver IGF-1 levels between the A and the EE groups (P = 0.013) and between the A and the A-EE groups (P = 0.02). No increase of IGF-1 level in rats treated with a combination of aerobic exercise and continuous EE may be due to IGF-1’s nonneural expression in the periphery and its synergistic effect with other growth factors.
ISSN:1097-9751