Renoprotective meroterpenoids from the fungus Ganoderma cochlear

Nine multifarious new meroterpenoids, cochlearols E-M (1–9), along with seven known meroterpenoids 10–16, were isolated from the fruiting bodies of Ganoderma cochlear. Racemic 1, 6–8, 10 and 13 were separated by chiral HPLC. The structures were elucidated based on detailed spectroscopic analyses (HR...

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Bibliographic Details
Published in:Fitoterapia 2019-01, Vol.132, p.88-93
Main Authors: Wang, Xin-Long, Wu, Ze-Hong, Di, Lei, Zhou, Feng-Jiao, Yan, Yong-Ming, Cheng, Yong-Xian
Format: Article
Language:English
Subjects:
Cell proliferation
Circular dichroism
Cochlea
Dichroism
ECD calculations
Fibrosis
Fruit bodies
Fungi
Ganoderma
Ganoderma cochlear
High-performance liquid chromatography
Liquid chromatography
Meroterpenoids
NMR
Nuclear magnetic resonance
Renal fibrosis
Transforming growth factor-b1
Two dimensional analysis
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Summary:Nine multifarious new meroterpenoids, cochlearols E-M (1–9), along with seven known meroterpenoids 10–16, were isolated from the fruiting bodies of Ganoderma cochlear. Racemic 1, 6–8, 10 and 13 were separated by chiral HPLC. The structures were elucidated based on detailed spectroscopic analyses (HRESIMS, 1D/2D-NMR) and calculated electronic circular dichroism (ECD). Their biological activities against renal fibrosis were evaluated by using rat normal and diseased renal interstitial fibroblast cells (NRK49F). The results show that compounds 7a, 7b, and 10a exhibit potent proliferation inhibition in TGF-β1-induced NRK-49F cells. [Display omitted]
ISSN:0367-326X
1873-6971
DOI:10.1016/j.fitote.2018.12.002