Mutagenicity testing for chemical risk assessment: update of the WHO/IPCS Harmonized Scheme

Since the publication of the International Programme on Chemical Safety (IPCS) Harmonized Scheme for Mutagenicity Testing, there have been a number of publications addressing test strategies for mutagenicity. Safety assessments of substances with regard to genotoxicity are generally based on a combi...

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Bibliographic Details
Published in:Mutagenesis 2009-07, Vol.24 (4), p.341-349
Main Authors: Eastmond, David A., Hartwig, Andrea, Anderson, Diana, Anwar, Wagida A., Cimino, Michael C., Dobrev, Ivan, Douglas, George R., Nohmi, Takehiko, Phillips, David H., Vickers, Carolyn
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Carcinogens
DNA Damage
Forecasting
Fundamental and applied biological sciences. Psychology
Germ Cells - drug effects
Humans
International Cooperation
Legislation as Topic
Molecular and cellular biology
Molecular genetics
Mutagenesis. Repair
Mutagenicity Tests - methods
Mutagens
Risk Assessment
World Health Organization
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Summary:Since the publication of the International Programme on Chemical Safety (IPCS) Harmonized Scheme for Mutagenicity Testing, there have been a number of publications addressing test strategies for mutagenicity. Safety assessments of substances with regard to genotoxicity are generally based on a combination of tests to assess effects on three major end points of genetic damage associated with human disease: gene mutation, clastogenicity and aneuploidy. It is now clear from the results of international collaborative studies and the large databases that are currently available for the assays evaluated that no single assay can detect all genotoxic substances. The World Health Organization therefore decided to update the IPCS Harmonized Scheme for Mutagenicity Testing as part of the IPCS project on the Harmonization of Approaches to the Assessment of Risk from Exposure to Chemicals. The approach presented in this paper focuses on the identification of mutagens and genotoxic carcinogens. Selection of appropriate in vitro and in vivo tests as well as a strategy for germ cell testing are described.
ISSN:0267-8357
1464-3804
DOI:10.1093/mutage/gep014