pH-Metric log P. 3. Glass electrode calibration in methanol-water, applied to pKa determination of water-insoluble substances

A series of semiaqueous HCl solutions of known concentration was titrated at 21, 25 and 37 degrees C with standardized KOH, pH 2-12. It is concluded that pKa determination for water-insoluble, methanol-soluble compounds may be reliably performed according to the described procedures.

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Bibliographic Details
Published in:Analytical chemistry (Washington) 1993-01, Vol.65 (1), p.42-49
Main Authors: Avdeef, Alex, Comer, John E. A, Thomson, Simon J
Format: Article
Language:English
Subjects:
Acids
Chemistry
Temperature
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Description
Summary:A series of semiaqueous HCl solutions of known concentration was titrated at 21, 25 and 37 degrees C with standardized KOH, pH 2-12. It is concluded that pKa determination for water-insoluble, methanol-soluble compounds may be reliably performed according to the described procedures.
ISSN:0003-2700
1520-6882
DOI:10.1021/ac00049a010