A Sample Concentrator for Sensitivity Enhancement in Chromatographic Analyses

A simple, inexpensive, fast, and sensitive method for improving detection limits using a novel sample concentrator is described. Analytes are concentrated on the tip of a GC syringe by evaporating the solvent with a flow of nitrogen. The increased sensitivity of the concentrator permits extraction w...

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Bibliographic Details
Published in:Analytical chemistry (Washington) 1998-05, Vol.70 (10), p.2191-2195
Main Authors: Galipo, Randolph C, Morgan, Stephen L, Brewer, William E
Format: Article
Language:English
Subjects:
Analytical chemistry
Chemistry
Chromatographic methods and physical methods associated with chromatography
Exact sciences and technology
Gas chromatographic methods
Instruments
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Description
Summary:A simple, inexpensive, fast, and sensitive method for improving detection limits using a novel sample concentrator is described. Analytes are concentrated on the tip of a GC syringe by evaporating the solvent with a flow of nitrogen. The increased sensitivity of the concentrator permits extraction with lower volumes, minimizes disposal costs, and simplifies sample preparation. The concentrator improved sensitivities for selected drugs (7.6−12.8 times), pesticides (12−17 times), and C11−C16 alkanes (1.5−6 times). With or without use of the concentrator, relative standard deviations of peak areas were less than 10%. Diverse GC and GC/MS applications ranging from forensic toxicology to environmental analysis can benefit from the improved detection limits provided by this concentrator design.
ISSN:0003-2700
1520-6882
DOI:10.1021/ac971218f