Disaggregation of Magnesium Octa[(4'-Benzo-15-Crown-5)Oxy]Phthalocyaninate in Aqueous Micellar Solutions of Alkyltriphenylphosphonium Bromide

— The behavior of magnesium octa[(4'-benzo-15-crown-5)oxy]phthalocyaninate (Mgcr 8 Pc) in aqueous micellar solutions of alkyltriphenylphosphonium bromides (C n TPPBs), where n = 8, 12, 14, and 16, has been studied by means of electronic absorption spectroscopy and measurements of fluorescence p...

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Bibliographic Details
Published in:Colloid journal of the Russian Academy of Sciences 2018-11, Vol.80 (6), p.667-675
Main Authors: Movchan, T. G., Chernyad’ev, A. Yu, Plotnikova, E. V., Averin, A. A., Tsivadze, A. Yu, Baulin, V. E.
Format: Article
Language:English
Subjects:
Bromides
Chemistry
Chemistry and Materials Science
Fluorescence
Ions
Magnesium
Photodynamic therapy
Polymer Sciences
Singlet oxygen
Surfaces and Interfaces
Thin Films
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Summary:— The behavior of magnesium octa[(4'-benzo-15-crown-5)oxy]phthalocyaninate (Mgcr 8 Pc) in aqueous micellar solutions of alkyltriphenylphosphonium bromides (C n TPPBs), where n = 8, 12, 14, and 16, has been studied by means of electronic absorption spectroscopy and measurements of fluorescence photophysical characteristics. Intense bands of absorption (λ max = 683 nm) and fluorescence (λ max = 694 nm) of Mgcr 8 Pc in C n TPPB micellar solutions are characterized by monoexponential decay of intensity (lifetime of 5.98–6.29 ns) and indicate that magnesium phthalocyaninate has the monomeric form. The disaggregation of Mgcr 8 Pc in the presence of C n TPPBs provides an opportunity to use aqueous micellar solutions containing this metallophthalocyane in photodynamic therapy, because it is the monomeric form of Mgcr 8 Pc that generates singlet oxygen molecules, which kill tumor cells.
ISSN:1061-933X
1608-3067
DOI:10.1134/S1061933X18060091