Disorders of renal NaCl transport and implications for blood pressure regulation

Hypertension is one of the major risk factors for cardiovascular disease in industrialized societies. Substantial progress has been made in understanding its epidemiology, its pathophysiology, and its associated risks such as coronary artery disease, stroke, and heart failure. Because there is conse...

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Bibliographic Details
Published in:Medizinische Genetik 2019-02, Vol.31 (1), p.1-7
Main Authors: Hennings, J. Christopher, Hübner, Christian A.
Format: Article
Language:English
Subjects:
Blood pressure
Bluthochdruck
Cardiovascular disease
Cardiovascular diseases
Congestive heart failure
Coronary artery
Coronary artery disease
Gene Therapy
Genetic disorders
Gynecology
Human Genetics
Hypertension
Hypertonia
Hypertonie
Ion transport
Ionentransport
Kidneys
Medicine
Medicine & Public Health
Natriumchlorid
Niere
Oncology
Reproductive Medicine
Risk factors
Sodium chloride
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Summary:Hypertension is one of the major risk factors for cardiovascular disease in industrialized societies. Substantial progress has been made in understanding its epidemiology, its pathophysiology, and its associated risks such as coronary artery disease, stroke, and heart failure. Because there is consensus that the abnormal retention of sodium by the kidney is a major important pathophysiological event in hypertension, this review focuses on mechanisms of renal NaCl transport and associated genetic disorders.
ISSN:0936-5931
1863-5490
DOI:10.1007/s11825-019-0232-8