Successful Treatment of Autophonia with Botulinum Toxin: Case Report

Objectives: We sought to treat autophonia due to a patulous eustachian tube using botulinum toxin. Methods: Because we assumed that the patulous eustachian tube was caused by abnormal activity of paratubal muscles (tensor and levator veli palatini muscles and salpingopharyngeus muscle), paralysis wa...

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Published in:Annals of otology, rhinology & laryngology rhinology & laryngology, 2007-08, Vol.116 (8), p.594-598
Main Authors: Olthoff, Arno, Laskawi, Rainer, Kruse, Eberhard
Format: Article
Language:English
Subjects:
Acoustic Impedance Tests
Audiometry, Pure-Tone
Biological and medical sciences
Botulinum Toxins, Type A - administration & dosage
Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology
Endoscopy
Eustachian Tube - drug effects
Eustachian Tube - physiopathology
Female
Follow-Up Studies
Humans
Injections, Intramuscular
Medical sciences
Middle Aged
Non tumoral diseases
Otorhinolaryngology. Stomatology
Palate, Soft - drug effects
Tinnitus - drug therapy
Tinnitus - physiopathology
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Summary:Objectives: We sought to treat autophonia due to a patulous eustachian tube using botulinum toxin. Methods: Because we assumed that the patulous eustachian tube was caused by abnormal activity of paratubal muscles (tensor and levator veli palatini muscles and salpingopharyngeus muscle), paralysis was performed via injection of botulinum toxin type A in a 45-year-old female professional musician who had had chronic unilateral autophonia for 20 years. In addition to a patient interview, an endoscopic examination of the nasopharynx (posterior rhinoscopy), ear microscopy, and impedance audiometry were performed to verify the diagnosis and the outcome after treatment. Results: The autophonia disappeared 1 week after treatment. Normalized tympanic ventilation was verified by impedance audiometry after 8 weeks. The period of symptom relief was 9 months. Conclusions: The administration of botulinum toxin type A provides a new option in the treatment of patulous eustachian tube. The reliability of this method and the effect of repeated injections remains to be proved in future studies.
ISSN:0003-4894
1943-572X
DOI:10.1177/000348940711600807