Oxymetazoline Solutions Inhibit Middle Ear Pathogens and are Not Ototoxic

• Published in: Annals of otology, rhinology & laryngology rhinology & laryngology, 2005-08, Vol.114 (8), p.645-651
• Main Authors: Isaacson, Glenn, Buttaro, Bettina A., Mazeffa, Valorie, Li, Geming, Frenz, Dorothy A.
• Format: Article
• Language: English
• Subjects: Adrenergic alpha-Agonists - administration & dosage; Adrenergic alpha-Agonists - adverse effects; Adrenergic alpha-Agonists - pharmacology; Aerosols; Animals; Bacteria - drug effects; Biological and medical sciences; Cell Count; Cochlea - drug effects; Cochlea - ultrastructure; Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology; Ear, Middle - drug effects; Ear, Middle - microbiology; Guinea Pigs; Hair Cells, Auditory, Outer - cytology; Hair Cells, Auditory, Outer - drug effects; Hair Cells, Auditory, Outer - ultrastructure; Medical sciences; Microbial Sensitivity Tests; Microscopy, Electron, Scanning; Non tumoral diseases; Ophthalmic Solutions; Otorhinolaryngology. Stomatology; Oxymetazoline - administration & dosage; Oxymetazoline - adverse effects; Oxymetazoline - pharmacology; Preservatives, Pharmaceutical - pharmacology; Solutions
• ISSN: 0003-4894; 1943-572X
• DOI: 10.1177/000348940511400811

Objectives: This study was performed to explore the antimicrobial activity of two commercially available oxymetazoline hydrochloride preparations against the common pathogens of otitis media and to demonstrate the lack of ototoxicity of these agents and of United States Pharmacopeia (USP) oxymetazoline in a standard animal model. Methods: Disc diffusion assays and minimum inhibitory concentration studies against American Type Culture Collection reference strains of common middle ear pathogens were used to evaluate the antimicrobial activity of oxymetazoline solutions and fluoroquinolone drops, and outer hair cell counts were performed on scanning electron micrographs of guinea pig basal cochlear segments after chronic exposure to oxymetazoline solutions and positive and negative controls. Results: Oxymetazoline nasal spray and eyedrops had activity against all species tested except Haemophilus influenzae and Pseudomonas aeruginosa. The USP oxymetazoline had limited antimicrobial activity. Oxymetazoline nasal spray, oxymetazoline eyedrops, and USP oxymetazoline had ototoxicity profiles indistinguishable from that of the saline solution control. Conclusions: Commercially available oxymetazoline solutions are active against several of the common pathogens of otitis media. This antimicrobial activity is not due to oxymetazoline, and is more likely due to preservatives present in the solutions. The solutions tested are not ototoxic to guinea pig outer hair cells. Oxymetazoline solutions are potential substitutes for broad-spectrum antibiotic drops after tympanostomy tube placement.