Peritoneal dialysis fluid-induced changes of the peritoneal membrane are reversible after peritoneal rest in rats

Background. Peritoneal dialysis (PD) is associated with functional and structural alterations of the peritoneal membrane. However, the (ir)reversibility of these pathological changes of the peritoneum is not understood fully. Methods. In an experimental PD model, rats (n = 15) received daily 10 ml c...

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Bibliographic Details
Published in:Nephrology, dialysis, transplantation dialysis, transplantation, 2005-01, Vol.20 (1), p.189-193
Main Authors: Zareie, Mohammad, Keuning, Eelco D., ter Wee, Piet M., Beelen, Robert H. J., van den Born, Jacob
Format: Article
Language:English
Subjects:
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Animals
Biological and medical sciences
Biopsy, Needle
cellular alterations
Dialysis Solutions - adverse effects
Dialysis Solutions - pharmacology
Disease Models, Animal
Emergency and intensive care: renal failure. Dialysis management
Epithelium - drug effects
Epithelium - pathology
Glomerulonephritis
Glucose - pharmacology
Immunohistochemistry
Intensive care medicine
Male
Medical sciences
morphological alterations
Neovascularization, Physiologic - physiology
Nephrology. Urinary tract diseases
Nephropathies. Renovascular diseases. Renal failure
Omentum - drug effects
Omentum - pathology
Peritoneal Dialysis - adverse effects
Peritoneal Dialysis - methods
peritoneal dialysis fluids
Peritoneal Diseases - etiology
Peritoneal Diseases - pathology
peritoneal membrane
peritoneal rest
Probability
Rats
Rats, Wistar
Renal failure
Sensitivity and Specificity
Statistics, Nonparametric
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Summary:Background. Peritoneal dialysis (PD) is associated with functional and structural alterations of the peritoneal membrane. However, the (ir)reversibility of these pathological changes of the peritoneum is not understood fully. Methods. In an experimental PD model, rats (n = 15) received daily 10 ml conventional glucose containing PD fluid, via peritoneal catheters connected to implanted subcutaneous mini vascular access ports. After 5 weeks of treatment, the first group of animals (PDF; n = 10) was sacrificed, while peritoneal catheters of the remaining group of rats (PD-rest; n = 5) were removed 1 week later. The latter group (PD-rest) was sacrificed 12 weeks after removing catheters. At both time points, untreated rats were included as controls. Cellular and morphological parameters were analysed by light and electron microscopy. Results. Rats exposed to PD fluid for 5 weeks showed a severe angiogenesis in various peritoneal tissues. Peritoneal rest resulted in a significant reduction in blood vessel density in visceral (mesentery, P
ISSN:0931-0509
1460-2385
DOI:10.1093/ndt/gfh559