Factors associated with increased plasma homocysteine in patients using an amino acid peritoneal dialysis fluid

Background. Although amino acid peritoneal dialysate (AAPD) substitution is thought to improve protein-energy malnutrition in patients undergoing peritoneal dialysis (PD), it may also increase plasma homocysteine (Hcy) levels due to the methionine load in the dialysate. However, it is still unclear...

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Bibliographic Details
Published in:Nephrology, dialysis, transplantation dialysis, transplantation, 2005-01, Vol.20 (1), p.161-166
Main Authors: Yang, Shao-Yu, Huang, Jenq-Wen, Shih, Kai-Yao, Hsu, Shih-Ping, Chu, Pei-Lun, Chu, Tzong-Shinn, Wu, Kwan-Dun
Format: Article
Language:English
Subjects:
Adult
amino acid peritoneal dialysate
Amino Acids - adverse effects
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
Dialysis Solutions - adverse effects
Dialysis Solutions - chemistry
Emergency and intensive care: renal failure. Dialysis management
Female
Follow-Up Studies
Glomerulonephritis
homocysteine
Homocysteine - blood
Homocysteine - metabolism
Humans
Hyperhomocysteinemia - diagnosis
Hyperhomocysteinemia - etiology
Intensive care medicine
Kidney Failure, Chronic - diagnosis
Kidney Failure, Chronic - therapy
Kidney Function Tests
Male
Malnutrition - physiopathology
Medical sciences
Middle Aged
Nephrology. Urinary tract diseases
Nephropathies. Renovascular diseases. Renal failure
nutrition
peritoneal dialysis
Peritoneal Dialysis - adverse effects
Peritoneal Dialysis - methods
Probability
Prospective Studies
Risk Assessment
Severity of Illness Index
Single-Blind Method
Statistics, Nonparametric
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the urinary system
Taiwan
Treatment Outcome
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Summary:Background. Although amino acid peritoneal dialysate (AAPD) substitution is thought to improve protein-energy malnutrition in patients undergoing peritoneal dialysis (PD), it may also increase plasma homocysteine (Hcy) levels due to the methionine load in the dialysate. However, it is still unclear which factors are important for elevating Hcy in patients treated with AAPD. Methods. Sixteen malnourished PD patients (age 48±18 years) were treated daily with one exchange of 1.1% AAPD for 3 months. The effects of AAPD on nutrition, Hcy, methionine, leptin and insulin resistance were studied. We also analysed factors that influenced plasma Hcy levels. Results. We found a transient increase in serum albumin (P
ISSN:0931-0509
1460-2385
DOI:10.1093/ndt/gfh554