Pre-dilution on-line haemofiltration vs low-flux haemodialysis: a randomized prospective study

Background. Accumulation of larger molecular weight uraemic toxins molecules may have a negative effect on the cardiovascular and nutritional state of dialysis patients and influence uraemic symptomatology. Their clearance can be enhanced by the use of haemofiltration (HF). Methods. The effects of l...

Full description

Saved in:
Bibliographic Details
Published in:Nephrology, dialysis, transplantation dialysis, transplantation, 2005-06, Vol.20 (6), p.1155-1163
Main Authors: Beerenhout, Charles H., Luik, Antinus J., Jeuken-Mertens, Suzan G. J., Bekers, Otto, Menheere, Paul, Hover, Linda, Klaassen, Leny, van der Sande, Frank M., Cheriex, Emile C., Meert, Natalie, Leunissen, Karel M., Kooman, Jeroen P.
Format: Article
Language:English
Subjects:
Aged
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
cardiovascular
Emergency and intensive care: infection, septic shock
Emergency and intensive care: renal failure. Dialysis management
Female
haemofiltration
Hemofiltration - methods
homocysteine
Humans
Intensive care medicine
left ventricular mass
Male
Medical sciences
Middle Aged
Nutritional Status
pre-dilution on-line
Prospective Studies
pulse wave velocity
Quality of Life
Renal Dialysis - methods
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the urinary system
Urea
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background. Accumulation of larger molecular weight uraemic toxins molecules may have a negative effect on the cardiovascular and nutritional state of dialysis patients and influence uraemic symptomatology. Their clearance can be enhanced by the use of haemofiltration (HF). Methods. The effects of low-flux haemodialysis (HD) (ultrapure dialysate; polyamide membranes) and pre-dilution on-line HF (1:1 blood/substitution ratio; target filtration volume: 1.2 times body weight) on cardiovascular and nutritional parameters, interdialytic levels of uraemic toxins and quality of life (QOL; Laupacis questionnaire) were assessed during 1 year follow-up. Forty patients were randomized. Results. After 1 year, 27 patients were eligible for analysis (HF: 13 patients; HD: 14 patients). Left ventricular mass index did not change in the HF patients (127±33 → 131±36 g/m2 after 12 months) or in the HD group (135±34 → 138±32 g/m2). Also, there were no changes in pulse wave velocity, and 48 h systolic and diastolic blood pressures. Lean body mass, assessed by dual-energy X-ray absorptiometry, increased in the HF group (44.8±8.9 → 46.2±9.6 kg; P
ISSN:0931-0509
1460-2385
DOI:10.1093/ndt/gfh775