Effects of doxorubicin on the structural and morphological characterization of solid lipid nanoparticles (SLN) using small angle neutron scattering (SANS) and small angle X-ray scattering (SAXS)

Cancer is still a major public health problem. Leaving detection of early stages of tumors and other issues aside, minimizing unwarranted side effects, for example after clinical usage of a liposomal anticancer drug doxorubicin (Dox) formulation, is an unmet clinical problem and the focus of many st...

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Bibliographic Details
Published in:Physica. B, Condensed matter Condensed matter, 2018-12, Vol.551, p.191-196
Main Authors: Yokaichiya, Fabiano, Schmidt, Christian, Storsberg, Joachim, Kumpugdee Vollrath, Mont, de Araujo, Daniele Ribeiro, Kent, Ben, Clemens, Daniel, Wingert, Friedrich, Franco, Margareth K.K.D.
Format: Article
Language:English
Subjects:
Cancer therapies
Coconut oil
Cosmetics
Doxorubicin
Drug carriers
Drug delivery systems
Formulations
Lipids
Molecular structure
Morphology
Mygliol
Nanoparticles
Neutron scattering
Public health
SANS
Scattering
Side effects
SLN
Small angle X ray scattering
Soybean
Soybean oil
Soybeans
Structural analysis
Surface structure
Tumors
Viability
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Summary:Cancer is still a major public health problem. Leaving detection of early stages of tumors and other issues aside, minimizing unwarranted side effects, for example after clinical usage of a liposomal anticancer drug doxorubicin (Dox) formulation, is an unmet clinical problem and the focus of many studies. Using compounds typically used in the preparation of food and/or cosmetics to prepare drug carrier systems, we observed that sodium tetradecyl sulfate (STS) containing and soybean-oil based carriers are more efficient in reducing the viability of HeLa cells tumor cells in comparison to their respective counterparts. Here, we probe the doxorubicin (Dox) loading on structural properties of either soybean oil or coconut oil (Mygliol 812) formulations. Small angle neutron scattering (SANS) assays were performed using V16 instrument at Helmholtz-Zentrum Berlin (HZB) at 25, 37 and 40 °C with two or 11 m distance between detector and sample to assess a wide range in scattering vector Q. Combined with previous measurement using small angle X-ray scattering (SAXS), our results show that the Dox has different influence in the surface structure of the solid lipid nanoparticles (SLN) and also affects the fractality in the vesicle aggregates when the concentration of the drug is altered, for Mygliol and soybean oil SLN drug delivery carrier systems.
ISSN:0921-4526
1873-2135
DOI:10.1016/j.physb.2017.12.036