Synthesis of novel 1,4 naphthoquinone-based molecules by an Ugi-type four-component reaction

In an attempt to further exploit multicomponent reactions in the field of 1,4 naphthoquinone-based compounds, we describe an Ugi-type multicomponent approach for the synthesis of novel 3-substituted 1,4 naphthoquinone molecules. The process relies on the execution of an enol-Ugi reaction between an...

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Bibliographic Details
Published in:Synthetic communications 2019-02, Vol.49 (4), p.515-521
Main Authors: Rabêlo, Waléria F., Echemendía, Radell
Format: Article
Language:English
Subjects:
Chemical synthesis
Diamines
Enols
isocyanide chemistry
multicomponent reactions
Organic chemistry
quinones
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Summary:In an attempt to further exploit multicomponent reactions in the field of 1,4 naphthoquinone-based compounds, we describe an Ugi-type multicomponent approach for the synthesis of novel 3-substituted 1,4 naphthoquinone molecules. The process relies on the execution of an enol-Ugi reaction between an enol-3-nitro-1,4 naphthoquinone with different secondary diamines and isocyanides. The novel methodology showed great chemical efficiency and versatility.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397911.2018.1551548