Hepatoprotective Potentials of Onion and Garlic Extracts on Cadmium-Induced Oxidative Damage in Rats

The hepatoprotective effect of onion and garlic extracts on cadmium (Cd)-induced oxidative damage in rats is reported. Control group received double-distilled water alone. Cd group was challenged with 3CdSO₄·8H₂O (as Cd; 1.5 mg/kg bw per day per oral) alone, while extract-treated groups were pretrea...

Full description

Saved in:
Bibliographic Details
Published in:Biological trace element research 2009-06, Vol.129 (1-3), p.143-156
Main Authors: Obioha, Udoka E, Suru, Stephen M, Ola-Mudathir, Kikelomo F, Faremi, Toyin Y
Format: Article
Language:English
Subjects:
Animals
Antioxidants
Biochemistry
Biomedical and Life Sciences
Biotechnology
Cadmium
Cadmium - toxicity
Catalase - metabolism
Distilled water
Garlic - chemistry
Hepatotoxicity
Herbs
Life Sciences
Liver - drug effects
Liver - enzymology
Liver - metabolism
Male
Nutrition
Oncology
Onions - chemistry
Oxidative Stress - drug effects
Peroxidation
Plant Extracts - pharmacology
Protective Agents - pharmacology
Rats
Rats, Wistar
Rodents
Studies
Superoxide Dismutase - metabolism
Toxicity
Trace elements
Vegetables
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The hepatoprotective effect of onion and garlic extracts on cadmium (Cd)-induced oxidative damage in rats is reported. Control group received double-distilled water alone. Cd group was challenged with 3CdSO₄·8H₂O (as Cd; 1.5 mg/kg bw per day per oral) alone, while extract-treated groups were pretreated with varied doses of onion and/or garlic extract (0.5 and 1.0 ml/100 g bw per day per oral) for a week and thereafter co-treated with Cd (1.5 mg/kg bw per day per oral) for 3 weeks. Cd caused a marked (p < 0.001) increase in the levels of lipid peroxidation and glutathione S-transferase, whereas glutathione, superoxide dismutase, and catalase levels were decreased in the liver. We also observed a decrease in hepatic activities of alanine transaminase (ALT), aspartate transaminase (AST), and alkaline phosphatase and a concomitant increase in the plasma activities of ALT and AST. Onion and garlic extracts significantly attenuated these adverse effects of Cd. Onion extract proffered a dose-dependent hepatoprotection. Our study showed that Cd-induced oxidative damage in rat liver is amenable to attenuation by high dose of onion and moderate dose of garlic extracts possibly via reduced lipid peroxidation and enhanced antioxidant defense system that is insufficient to prevent and protect Cd-induced hepatotoxicity.
ISSN:0163-4984
1559-0720
DOI:10.1007/s12011-008-8276-7