Mesenchymal stem cell: Basic research and potential applications in cattle and buffalo

Characteristic features like self‐renewal, multilineage differentiation potential, and immune‐modulatory/anti‐inflammatory properties, besides the ability to mobilize and home distant tissues make stem cells (SCs) a lifeline for an individual. Stem cells (SCs) if could be harvested and expanded with...

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Bibliographic Details
Published in:Journal of cellular physiology 2019-06, Vol.234 (6), p.8618-8635
Main Authors: Gugjoo, Mudasir Bashir, Amarpal, Fazili, Mujeeb R, Shah, Riaz A, Sharma, Gutulla Taru
Format: Article
Language:English
Subjects:
Alternations
Animals
Bovidae
Buffalo
Buffaloes
Cattle
Cattle Diseases - surgery
Cell culture
Cell Culture Techniques - veterinary
Cell Differentiation
Cell Lineage
Cell Proliferation
Cell Self Renewal
Cell Separation - veterinary
Cells, Cultured
characterization
clinical applications
culture characteristics
Domestic animals
Fetuses
In vivo methods and tests
Inflammation
mesenchymal stem cell (MSCs)
Mesenchymal Stem Cell Transplantation - veterinary
Mesenchymal Stem Cells - immunology
Mesenchymal Stem Cells - metabolism
Mesenchymal Stem Cells - physiology
Mesenchyme
Physiological effects
Species Specificity
Stem cell transplantation
Stem cells
Teratogens
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Summary:Characteristic features like self‐renewal, multilineage differentiation potential, and immune‐modulatory/anti‐inflammatory properties, besides the ability to mobilize and home distant tissues make stem cells (SCs) a lifeline for an individual. Stem cells (SCs) if could be harvested and expanded without any abnormal change may be utilized as an all‐in‐one solution to numerous clinical ailments. However, slender understanding of their basic physiological properties, including expression potential, behavioral alternations during culture, and the effect of niche/microenvironment has currently restricted the clinical application of SCs. Among various types of SCs, mesenchymal stem cells (MSCs) are extensively studied due to their easy availability, straightforward harvesting, and culturing procedures, besides, their less likelihood to produce teratogens. Large ruminant MSCs have been harvested from various adult tissues and fetal membranes and are well characterized under in vitro conditions but unlike human or other domestic animals in vivo studies on cattle/buffalo MSCs have mostly been aimed at improving the animals’ production potential. In this document, we focused on the status and potential application of MSCs in cattle and buffalo.
ISSN:0021-9541
1097-4652
DOI:10.1002/jcp.27846