Polyhexamethylenebiguanide Hydrochloride Exposure and Erythema Multiforme in a Physician

A 52-year-old woman physician developed recurrent erythema multiforme. Occupational and environmental exposure assessment suggested a disinfectant containing polyhexamethylenebiguanide hydrochloride (PHMB), Phagosept ®. Elimination of the product was followed by disappearance of symptomatology. Lite...

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Bibliographic Details
Published in:International journal of occupational medicine and environmental health 2006, Vol.19 (1), p.81-82
Main Authors: Gehanno, Jean-François, Priot, Anne-Emmanuelle, Balguerie, Xavier, Caillard, Jean-François
Format: Article
Language:English
Subjects:
Biguanides - adverse effects
Erythema multiforme
Erythema Multiforme - physiopathology
Female
France
Humans
Middle Aged
Occupational Exposure
Physicians
Polyhexamethylenebiguanide hydrochloride
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Summary:A 52-year-old woman physician developed recurrent erythema multiforme. Occupational and environmental exposure assessment suggested a disinfectant containing polyhexamethylenebiguanide hydrochloride (PHMB), Phagosept ®. Elimination of the product was followed by disappearance of symptomatology. Literature search revealed cases of sensitization and anaphylaxis due to contact with PHMB, but to our knowledge, this is the first report on PHMB-induced erythema multiforme.
ISSN:1232-1087
1896-494X
DOI:10.2478/v10001-006-0002-0