Non-viral nanocarriers for intracellular delivery of microRNA therapeutics

MicroRNAs are small regulatory noncoding RNAs that regulate various biological processes associated with neurological disorders, cardiovascular diseases, cancer and viral infection. MiRNA-based therapeutics have broad applications including cancer immunotherapy, genomic engineering and protein repla...

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Bibliographic Details
Published in:Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2019-02, Vol.7 (8), p.129-1225
Main Authors: Bai, Zhiman, Wei, Jing, Yu, Changmin, Han, Xisi, Qin, Xiaofei, Zhang, Chengwu, Liao, Wenzhen, Li, Lin, Huang, Wei
Format: Article
Language:English
Subjects:
Biological activity
Cancer
Cancer immunotherapy
Cardiovascular diseases
Heart diseases
Immunotherapy
In vivo methods and tests
Intracellular
Lipids
miRNA
Nanoparticles
Neurological diseases
Protein engineering
Proteins
Ribonucleic acid
RNA
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Summary:MicroRNAs are small regulatory noncoding RNAs that regulate various biological processes associated with neurological disorders, cardiovascular diseases, cancer and viral infection. MiRNA-based therapeutics have broad applications including cancer immunotherapy, genomic engineering and protein replacement therapy. Until now, a variety of materials have been proved to be promising as non-viral nanocarriers for intracellular delivery of miRNAs, such as polymeric nanoparticles, lipid nanocapsules, and inorganic nanoparticles, etc. In this review, we will present the strategies for intracellular miRNA delivery, and specially focus on rationally designed routes, their mechanisms of action, and potential therapeutics used in the host cells or in vivo studies. Futhermore, we will also make a conclusion based on the current development. The perspective on the new generation of delivery systems toward the emerging area of miRNA-based therapeutics will be discussed as well. MicroRNAs are small regulatory noncoding RNAs that regulate various biological processes. Herein, we will present the development of the strategies for intracellular miRNAs delivery, and specially focus on the rational designed routes, their mechanisms of action, as well as potential therapeutics used in the host cells or in vivo studies.
ISSN:2050-750X
2050-7518
DOI:10.1039/c8tb02946f