Fixed dose 4-factor prothrombin complex concentrate for bleeding caused by long acting anticoagulant rodenticides

Acute, unintentional drug-related poisonings lead to an estimated 418,313 ED visits in 2014, according to the latest statistics from the Center for Disease Control and Prevention. While most of these were opiate-related poisonings, anticoagulant rodenticides were the most common cause of rodenticide...

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Bibliographic Details
Published in:The American journal of emergency medicine 2018-10, Vol.36 (10), p.1922.e3-1922.e4
Main Authors: Doyle, Richard J., Elfessi, Zane, Kolman, Kevin
Format: Article
Language:English
Subjects:
Abdomen
Anticoagulants
Brodifacoum
Case reports
Difenacoum
Drug dosages
Emergency medical care
Hemoglobin
Hemorrhage
Ingestion
Pain
Patients
Poisoning
Prothrombin
Prothrombin complex concentrates
Rodenticides
Thrombosis
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Summary:Acute, unintentional drug-related poisonings lead to an estimated 418,313 ED visits in 2014, according to the latest statistics from the Center for Disease Control and Prevention. While most of these were opiate-related poisonings, anticoagulant rodenticides were the most common cause of rodenticide-related poisoning in the United States. Many clinical syndromes and treatment algorithms have been described for patients with anticoagulant rodenticide poisoning. We report a case of an acute ingestion of two anticoagulant rodenticides and successful reversal of coagulation parameters using 4-factor prothrombin complex concentrate in a fixed-dose approach.
ISSN:0735-6757
1532-8171
DOI:10.1016/j.ajem.2018.06.040